Measurement and evaluation of thiamine concentrations in the blood of Australians who have a history of Diagnostic and Statistical Manual Fourth Edition(DSM IV) alcohol dependence or abuse, after 20 years of supplementing flour with thiamine.

Not Applicable

Recruiting

• Conditions: Wernicke-Korsakoff syndrome; Alcohol Dependence; Thiamine Deficiency; Alcohol Abuse; Neurological - Dementias; Mental Health - Addiction; Public Health - Epidemiology

• Registration Number: ACTRN12610000661077
• Lead Sponsor: Dr Philip Crowley, M.B.B.S., F.R.A.C.G.P., Grad. Dip. Mgt., Trainee R.A.C.P. Chapter of Addiction Medicine, Senior Medical Officer, Drug and Alcohol Services South Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-08-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

Selection Criteria
1.Require assessment for DSM IV Alcohol Dependence by the Driver Assessment Clinic of Drug and Alcohol Services South Australia as a result of multiple driving under the influence of alcohol convictions
2.Able to provide a valid consent to participate in the study

Exclusion Criteria

1.Those who have had the surgical procedures: gastrectomy, gastrojejunostomy, partial or total colectomy, gastric bypasses surgery, vertical banded gastroplastyor obesity therapy with an intragastric balloon.
2.Patients who have had recurrent vomiting or chronic diarrhoea resulting from anorexia nervosa, pancreatitis and hyperemnesis gravidarum.
3.Those who have had the following cancer and related conditions: gastric or colon carcinoma, non Hodgkin’s lymphoma, myelomonocitic leukaemia, large B cell lymphoma, myeloid leukaemia, allogenic bone marrow transplantation, acquired immune deficiency syndrome.
4.Those who have renal disease requiring dialysis.
5.Magnesium depletion can result from chronic diuretic therapy, intestinal tract resection and Crohn’s disease. Patients with these conditions would be excluded from this aspect of the study

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Median serum thiamine phyrophosphate of the population with alcohol dependence and alcohol abuse[Data collected over a 2 month time period]

Secondary Outcome Measures

Name	Time	Method
Median serum Magnesium levels of the population with alcohol dependence and alcohol abuse[Data collected over a 2 month time period]