ACTRN12616000329460已完成1 期
The effect of chitosan-dextran (Chitodex) gel with budesonide and mupirocin on recalcitrant rhinosinusitis
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 38
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Selection/inclusion criteria:
- •Patients who meet ALL of the following criteria will be offered inclusion in the study:
- •(1)Those who have had symptoms of chronic rhinosinusitis (nasal discharge, postnasal drip, nasal obstruction, facial pain and pressure, lack of sense of smell) that has been previously persistent for greater than 3 months AND
- •(2)have had at least one operation for their chronic rhinosinusitis > 12 weeks prior to enrolment AND
- •(3)continue to have ongoing symptoms despite surgical management AND
- •(4)have not responded to at least one course of oral antibiotics
- •(5)have a positive sinonasal swab that indicates infection of the sinuses AND
- •(6)are over 18 years of age AND
- •(7)are able to give written informed consent AND
- •(8)are local patients who will be returning to this centre for postoperative follow-up care
排除标准
- •(1)allergy to shellfish, steroids or mupirocin
- •(2)pregnant or breastfeeding
- •(3)immunodeficient patients (patients on any immunosuppressive or immunomodulatory agent)
- •(4)on other CYP450 inhibiting drugs (e.g. ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin)
- •(5)liver disease
研究者
相似试验
已完成
1 期
The effect of chitosan-dextran (Chitodex) gel with budesonide and mupirocin in chronic rhinosinusitis patients post endoscopic sinonasal surgeryRespiratory - Other respiratory disorders / diseasesInfection - Other infectious diseasesInflammatory and Immune System - Other inflammatory or immune system disordersChronic RhinosinusitisACTRN12617000072314The Queen Elizabeth Hospital57
招募中
1 期
The effect of chitosan-dextran (Chitodex) gel with budesonide and ropivacaine on pain and wound healing following endoscopic sinus surgeryChronic RhinosinusitisRespiratory - Other respiratory disorders / diseasesAnaesthesiology - Pain managementACTRN12615000276550The Department of ENT, University of Adelaide48
招募中
1 期
Effect of novel drug with Chitodex gel on wound healing post endoscopic sinus surgery in the treatment of Chronic Rhinosinusitis (CRS)Chronic Rhino-SinusitisChronic recalcitrant sinusitisSurgery - Other surgeryInfection - Other infectious diseasesACTRN12618000577213The University of Adelaide90
尚未招募
1 期
The effect of chitosan based prepared gel on healing Grade 2 and 3 woundsgrade 2 and 3 wounds.IRCT20210510051243N2Arak University of Medical Sciences20
尚未招募
3 期
the effect of chitosan/aloe vera gel loaded with zinc oxide nanoparticles in treatment of wounds after gynecological surgeriesIRCT20230629058615N2Iran University of Medical Sciences66