Targeted Therapy to Increase RAI Uptake in Metastatic DTC

Recruiting

• Conditions: Pediatric Cancer; Differentiated Thyroid Cancer; Papillary Thyroid Cancer
• Interventions: Procedure: Whole body scan

• Registration Number: NCT05024929
• Lead Sponsor: Children's Hospital of Philadelphia

Brief Summary

Papillary thyroid cancer (PTC) is a common type of differentiated thyroid cancer (DTC) in children and represents the second most common cancer in adolescent females. Recently targeted drugs that block many of the genetic drivers of DTC have become available. While Investigators know that these drugs shrink DTC tumors in many cases, the impact on radioactive iodine (RAI) avidity has not been systematically studied.

Detailed Description

This is an observational cohort study that will enroll patients with DTC metastatic to the lungs who will receive oncogene-specific targeted therapy as part of routine clinical care or a separate therapeutic clinical trial. After approximately 4 weeks of therapy, patients will have a whole body scan to determine the change in RAI-avidity of their tumor from baseline. Subsequent therapy will be at the discretion of the treating physician or according to the therapeutic trial on which the patient is enrolled.

Study Timeline

• Study Start: 2021-07-16
• Study First Submitted: 2021-08-23
• Study First Submitted QC: 2021-08-23
• Study First Posted: 2021-08-27
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-09
• Last Update Posted: 2025-04-11
• Primary Completion: 2031-02-01
• Study Completion: 2033-02-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Prospective Cohort	Whole body scan	Patients with differentiated thyroid cancer for whom oncogene-specific targeted therapy is planned from commercial supply or as part of a separate therapeutic trial

Primary Outcome Measures

Name	Time	Method
Proportion of patients with increased tumor RAI-avidity after receiving oncogene-specific, targeted therapy	up to 5 years	The primary outcome measure is to determine the proportion of patients with differentiated thyroid cancer metastatic to the lungs for whom oncogene-specific, targeted therapy increases tumor RAI-avidity.

Trial Locations

Locations (9)

University of California San Francisco; 🇺🇸 San Francisco, California, United States

Emory University School of Medicine; 🇺🇸 Atlanta, Georgia, United States

St. Jude Children's Research Hospital; 🇺🇸 Memphis, Tennessee, United States

Children's Hospital Westmead; 🇦🇺 Sydney, New South Wales, Australia

Boston Children's Hospital; 🇺🇸 Boston, Massachusetts, United States

Children's Hospital of Philadelphia; 🇺🇸 Philadelphia, Pennsylvania, United States

MD Anderson Cancer Center; 🇺🇸 Houston, Texas, United States

Texas Children's Hospital; 🇺🇸 Houston, Texas, United States

Seattle Children's Hospital; 🇺🇸 Seattle, Washington, United States