Investigating changes in the human stretch reflex characteristics with Transcranial Magnetic Stimulation applied in the refractory period between the short and long latency reflex response

Completed

• Conditions: stroke; 10028037

• Registration Number: NL-OMON34193
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- Age between 40-70

Exclusion Criteria

cardiac pacemakers; any metal implant within the brain;any medical history of general and local neurological disorders, especially epilepsy; any history of orthopedic problems with the upper extremities; current medication that may influence nervous function.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome parameter is the amplitude of the M2 response as assessed by<br /><br>EMG activity. Dependents are characteristics of ramp-and-hold stretches and<br /><br>timed TMS pulses. Repeated measures Analysis of Variance will be applied for<br /><br>statistical analysis. Statistical significant differences of 30% in normalized<br /><br>M2 amplitude will confirm CNS modulation of peripheral reflex activity.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>