Light Therapy for Obsessive-compulsive Disorder (OCD)

Early Phase 1

Recruiting

• Conditions: OCD

• Registration Number: NCT06720090
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The goal of this clinical trial is to test whether light therapy is effective for reducing symptoms in young adults with OCD and late bedtimes (1am or later). The main question\[s\] it aims to answer are:
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Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2024-11
• Study First Submitted: 2024-11-21
• Study Start: 2024-12
• Study First Submitted QC: 2024-12-02
• Last Update Submitted: 2024-12-02
• Study First Posted: 2024-12-06
• Last Update Posted: 2024-12-06
• Primary Completion: 2029-03
• Study Completion: 2029-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Primary DSM-5 OCD diagnosis
2. Bedtime 0100 or later
3. Age 18-35
4. English speaking

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Exclusion Criteria

1. Subjects must not be currently participating in another research study that would influence their participation in our study.
2. Diagnostic status
3. Treatment status
4. Night shift work or travel more than 1 time zone outside of Central Standard Time (CST) in the past month
5. Pregnancy status
6. Medication status
7. Regular nicotine or marijuana use

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Yale Brown Obsessive-Compulsive Scale (YBOCS)	Administered at baseline, in treatment week 3, and post-treatment (3 administrations over 7 weeks)	A retrospective clinical interview of OCD symptom severity. Score range from 0 to 40 and higher scores indicate more severe OCD symptoms.
Daily Perseverative Thinking Questionnaire	Administered 4 times/day for 2 weeks at baseline, 4 times/day for 1 week in treatment week 3, and 4 times/day for 1 week in treatment week 5	Self-report measure of momentary transdiagnostic repetitive negative thinking. Score range from 6 to 42 and higher scores indicate more severe repetitive negative thinking.

Secondary Outcome Measures

Name	Time	Method
Circadian melatonin phase	At baseline and post-treatment (after 5 weeks of treament)	Dim light melatonin onset assessed by taking hourly saliva samples in dim light conditions for 10 hours beginning 7 hours before typical bedtime and ending 2 hours after typical bedtime.

Trial Locations

Locations (1)

Washington University; 🇺🇸 St. Louis, Missouri, United States