Evaluation of Neuropsychological Effects of Drug-resistant Anterior Temporal Epilepsy and Anterior Temporal Lobectomy in Face Perception
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals
Study Overview
Brief Summary
The purpose is to evaluate neuropsychological effects of anterior temporal epilepsy in face perception by comparison of performances of epileptic patients and control individuals, sex-, age- and socio-educational level-matched.
Secondary purposes are to prospectively evaluate neuropsychological impact of anterior temporal lobectomy performed for surgical treatment of anterior temporal epilepsy on face perception (exploratory study).
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Informed consent
- •Affiliation to social security
- •Preliminary medical examination
- •PATIENTS WITH EPILEPSY:
- •Symptomatic drug-resistant anterior temporal epilepsy (confirmed with video-electroencephalography and magnetic resonance imaging and if necessary intracerebral SEEG exploration)
- •Patient needing anterior temporal lobectomy and undergoing pre-surgery conventional intercritical assessment for surgery decision
- •Nonverbal IQ ≥ 70 (WAIS-IV)
- •At least 6 successful VOSP tests (perception test)
Exclusion Criteria
- •persons under legal protection or incapable to consent
- •Persons deprived of liberty by juridical or administrative decision
- •PATIENTS WITH EPILEPSY:
- •Sever visual disorders of neurological or ophthalmological origin
- •CONTROL INDIVIDUALS:
- •Psychiatric or neurological disorders
- •Important ophthalmological disorders
Arms & Interventions
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Mooney test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Benton Face Recognition test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Face inversion effect test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Face composite effect test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Cambridge Face Memory Test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Matching different view test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Memorizing and recognition of new faces test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Memorizing and recognition of new objects test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Recognition of celebrities and access to semantic information test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Intervention: Lobectomy (Procedure)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Mooney test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Benton Face Recognition test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Face inversion effect test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Face composite effect test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Cambridge Face Memory Test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Matching different view test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Memorizing and recognition of new faces test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Memorizing and recognition of new objects test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Intervention: Recognition of celebrities and access to semantic information test (Other)
Outcomes
Primary Outcomes
Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals
Time Frame: day 0
Secondary Outcomes
- Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals)(day 0 and after 24 to 30 months)