Anterior Temporal Epilepsy Neuropsychological Assessment of Faces

Not Applicable

• Conditions: Anterior Temporal Lobectomy; Anterior Temporal Epilepsy; Face Perception
• Interventions: Other: Mooney test; Other: Benton Face Recognition test; Other: Face inversion effect test; Other: Face composite effect test; Other: Cambridge Face Memory Test; Other: Matching different view test; Other: Memorizing and recognition of new faces test; Other: Memorizing and recognition of new objects test; Other: Recognition of celebrities and access to semantic information test; Procedure: Lobectomy

• Registration Number: NCT02888925
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

The purpose is to evaluate neuropsychological effects of anterior temporal epilepsy in face perception by comparison of performances of epileptic patients and control individuals, sex-, age- and socio-educational level-matched.

Secondary purposes are to prospectively evaluate neuropsychological impact of anterior temporal lobectomy performed for surgical treatment of anterior temporal epilepsy on face perception (exploratory study).

Detailed Description

Not available

Study Timeline

• Study Start: 2013-08
• Study First Submitted: 2016-08-31
• Study First Submitted QC: 2016-08-31
• Study First Posted: 2016-09-05
• Primary Completion: 2017-09
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-23
• Last Update Posted: 2019-07-24
• Study Completion: 2020-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

ALL:

• Informed consent
• Affiliation to social security
• Preliminary medical examination

PATIENTS WITH EPILEPSY:

• Symptomatic drug-resistant anterior temporal epilepsy (confirmed with video-electroencephalography and magnetic resonance imaging and if necessary intracerebral SEEG exploration)
• Patient needing anterior temporal lobectomy and undergoing pre-surgery conventional intercritical assessment for surgery decision
• Nonverbal IQ ≥ 70 (WAIS-IV)
• At least 6 successful VOSP tests (perception test)

Exclusion Criteria

ALL:

• persons under legal protection or incapable to consent
• Persons deprived of liberty by juridical or administrative decision

PATIENTS WITH EPILEPSY:

• Sever visual disorders of neurological or ophthalmological origin

CONTROL INDIVIDUALS:

• Psychiatric or neurological disorders
• Important ophthalmological disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Epilepsy	Face inversion effect test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Control	Benton Face Recognition test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Control	Mooney test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Control	Memorizing and recognition of new faces test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Epilepsy	Benton Face Recognition test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Epilepsy	Face composite effect test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Epilepsy	Memorizing and recognition of new objects test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Epilepsy	Mooney test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Epilepsy	Cambridge Face Memory Test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Epilepsy	Matching different view test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Epilepsy	Memorizing and recognition of new faces test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Epilepsy	Recognition of celebrities and access to semantic information test	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Epilepsy	Lobectomy	Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
Control	Face inversion effect test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Control	Matching different view test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Control	Memorizing and recognition of new objects test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Control	Recognition of celebrities and access to semantic information test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Control	Face composite effect test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
Control	Cambridge Face Memory Test	Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)

Primary Outcome Measures

Name	Time	Method
Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals	day 0

Secondary Outcome Measures

Name	Time	Method
Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals)	day 0 and after 24 to 30 months

Trial Locations

Locations (1)

Service de Neurologie, Hôpital Central, CHU de Nancy; 🇫🇷 Nancy, France