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Clinical Trials/ISRCTN12196183
ISRCTN12196183CompletedPhase 4

The effects of sodium valproate and oxcarbazepine on semen, sex hormones and sexual function in young male patients with epilepsy

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital0 sites77 target enrollmentStarted: April 26, 2020Last updated:
Conditions
Drugs

Trial Snapshot

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Observational

Eligibility Criteria

Sex
Male

Inclusion Criteria

  • 1. Patients with simple partial seizures, complex partial seizures or secondarily generalized seizures
  • 2. Healthy young male volunteers (control group)

Exclusion Criteria

  • 1. Use of hormones, antidepressants, or drugs to improve sexual function
  • 2. Liver and kidney dysfunction, thyroid disease, diabetes, infectious diseases, varicocele, cryptorchidism, history of testicular surgery, Klinefelter syndrome, or urinary system diseases
  • 3. Long-term alcoholism, smoking, or exposure to toxic substances
  • 4. Mental illness, intracranial occupying lesions, brain injury, or progressive degeneration of the nervous system
  • 5. Inability to cooperate or refusal to participate in the study
  • Individual participation in the study was terminated if any of the following conditions were met:
  • 1. Patients experienced adverse drug reactions after taking the medications and needed to discontinue the drug
  • 2. Patients failed to achieve an ideal treatment effect (i.e., the reduction in the frequency of epileptic seizures is less than 75% after three months of treatment), and other AEDs needed to be substituted or added
  • 3. Patients or volunteers took medications or suffered from diseases that might affect the results during the study
  • 4. Participants withdrew from the study for personal reasons

Investigators

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