A study of the effects of drugs used to treat epilepsy on semen, sex hormones and sexual function in young male patients with epilepsy
- Conditions
- EpilepsyNervous System Diseases
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 77
1. Patients with simple partial seizures, complex partial seizures or secondarily generalized seizures
2. Healthy young male volunteers (control group)
1. Use of hormones, antidepressants, or drugs to improve sexual function
2. Liver and kidney dysfunction, thyroid disease, diabetes, infectious diseases, varicocele, cryptorchidism, history of testicular surgery, Klinefelter syndrome, or urinary system diseases
3. Long-term alcoholism, smoking, or exposure to toxic substances
4. Mental illness, intracranial occupying lesions, brain injury, or progressive degeneration of the nervous system
5. Inability to cooperate or refusal to participate in the study
Individual participation in the study was terminated if any of the following conditions were met:
1. Patients experienced adverse drug reactions after taking the medications and needed to discontinue the drug
2. Patients failed to achieve an ideal treatment effect (i.e., the reduction in the frequency of epileptic seizures is less than 75% after three months of treatment), and other AEDs needed to be substituted or added
3. Patients or volunteers took medications or suffered from diseases that might affect the results during the study
4. Participants withdrew from the study for personal reasons
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quality of semen measured using lab test of semen sample at baseline and six months
- Secondary Outcome Measures
Name Time Method <br> 1. Sex hormones measured using lab test of blood sample at baseline and six months<br> 2. Sexual function measured using International Index of Erectile Function 5 (IIEF-5) at baseline and six months<br>