The effects of sodium valproate and oxcarbazepine on semen, sex hormones and sexual function in young male patients with epilepsy

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital0 sites77 target enrollmentStarted: April 26, 2020Last updated: May 4, 2020

Conditions

Drugs

Trial Snapshot

Phase: Phase 4
Status: Completed
Sponsor: Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Enrollment: 77

No summary available.

•1. Patients with simple partial seizures, complex partial seizures or secondarily generalized seizures
•2. Healthy young male volunteers (control group)

•1. Use of hormones, antidepressants, or drugs to improve sexual function
•2. Liver and kidney dysfunction, thyroid disease, diabetes, infectious diseases, varicocele, cryptorchidism, history of testicular surgery, Klinefelter syndrome, or urinary system diseases
•3. Long-term alcoholism, smoking, or exposure to toxic substances
•4. Mental illness, intracranial occupying lesions, brain injury, or progressive degeneration of the nervous system
•5. Inability to cooperate or refusal to participate in the study
•Individual participation in the study was terminated if any of the following conditions were met:
•1. Patients experienced adverse drug reactions after taking the medications and needed to discontinue the drug
•2. Patients failed to achieve an ideal treatment effect (i.e., the reduction in the frequency of epileptic seizures is less than 75% after three months of treatment), and other AEDs needed to be substituted or added
•3. Patients or volunteers took medications or suffered from diseases that might affect the results during the study
•4. Participants withdrew from the study for personal reasons

Sponsor