Adaptation of Melodic Intonation Therapy to Spanish

Not Applicable

Completed

• Conditions: Post Stroke Aphasia
• Interventions: Other: Melodic Intonation Therapy

• Registration Number: NCT03433495
• Lead Sponsor: Instituto de Investigación Hospital Universitario La Paz

Brief Summary

This study was conducted in three phases:

The first phase involved creation of a Spanish adaptation of the Melodic Intonation therapy; the second phase consisted of a pilot non-randomized intervention study to analyse its feasibility for use with 4 Spanish patients with poststroke nonfluent aphasia; the third phase consisted of a pilot randomised, crossover, intervention pilot trial in a different set of patients with poststroke nonfluent aphasia (N=20)

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02
• Primary Completion: 2016-02
• Study Completion: 2016-07
• Status Verified: 2018-02
• Study First Submitted: 2018-02-08
• Study First Submitted QC: 2018-02-13
• Last Update Submitted: 2018-02-13
• Study First Posted: 2018-02-14
• Last Update Posted: 2018-02-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients diagnosed with nonfluent aphasia due to unilateral stroke in the left hemisphere without neuroimaging evidence of lesions in the right hemisphere who fulfilled the following criteria:

• The time elapsed since the stroke exceeded 6 months.

• Patient had received a standard program of conventional speech therapy after stroke.

• Persistent nonfluent aphasia with the following characteristics:

  • Severely restricted language, which might be limited to meaningless stereotypy; unlike that observed in verbal tasks, the patient might produce some real and relevant words when singing familiar songs.
  • Poor repetition, even for single words.
  • Moderately preserved language comprehension.
  • The nonstereotyped language was produced with a slurring of speech.
  • The total score for the repetition did not exceed the 70th percentile in the Boston Diagnostic Aphasia Examination. The score was obtained from the average score in three areas: repetition of words and repetition of phrases; listening comprehension exceeding the 15th percentile of Boston Diagnostic Aphasia Examination; and from the average score obtained in three areas: word comprehension, commands and complex ideational material.

• The patient was motivated, emotionally stable and had good attention.

• Signed informed consent was provided.

Exclusion Criteria

• patients with a history of a previous stroke other than the index event or with any clinical condition (e.g., short life expectancy, coexisting disease) or other characteristics that precluded appropriate follow-up in the study
• patients participating in any therapeutic intervention clinical trials evaluating poststroke recovery
• use of psychotropic drugs that interfere with patient evaluation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Melodic Intonation Therapy	Melodic Intonation Therapy	The duration of therapy was 12 sessions performed over a 6-week period. Each session lasted 30 minutes. They were performed individually by a speech-experienced therapist previously trained in Melodic Intonation Therapy.

Primary Outcome Measures

Name	Time	Method
Boston Diagnostic Aphasia Examination	6 weeks after the end of therapy
Communicative Activity Log questionnaire	6 weeks after the end of therapy