The Prognostic Impact of Extracapsular Lymph Node Involvement (ECLNI) in Ductal Pancreatic Adenocarcinoma (DPAC).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- Overall cancer-specific survival
研究概览
简要总结
Extracapsular lymph node involvement (ECLNI) has been identified as a pathological variable associated with worse outcome in esophageal, gastric and colorectal cancer. No studies so far have studied its prognostic impact in ductal pancreatic adenocarcinoma (DPAC). The goal of the investigators is to determine the prognostic value of ECLNI in a prospective consecutive series of 145 patients with DPAC, who underwent resection of their primary tumor between 1998 and 2005.
详细描述
Presence and extent of extracapsular lymph node involvement (ECLNI) will be scored by reviewing all original pathological slides.
ECLNI is defined as metastatic adenocarcinoma extending through the nodal capsule into the perinodal fatty tissue.
Observers: 1 experienced board-certified GI pathologist, blinded for follow-up results.
Follow-up data are obtained by reviewing patients charts and by a telephone survey of the patient's GP/gastroenterologist in November 2007.
Statistical analysis:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary resection
排除标准
- •Positive section margins
- •non DPAC, other tumor
- •Postoperative mortality
- •Neoadjuvant chemo/radiotherapy
结局指标
主要结局
Overall cancer-specific survival
时间窗: 11/2007
次要结局
- Disease-free survival (DFS)& Correlation of ECLNI with other pathological variables(11/2007)