Prediction of Lymph Node Invasion in Patients Operated on for Prostate Adenocarcinoma
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Predicted risk of lymph-node involvement vs Briganti 2017
研究概览
简要总结
Despite lymph node involvement (LNI) being one of the main prognostic factors in patients with prostate cancer (PCa), pelvic lymph node irradiation remains debated, possibly due to an insufficient selection of patients. Significant advances in LNI risk modelling have been achieved with the addition of visual interpretation of magnetic resonance imaging (MRI) data, but it is likely that quantitative analysis could further improve prediction models. In this study, the investigators aimed to develop and internally validate a novel LNI risk prediction model based on radiomic features extracted from pre-operative multimodal MRI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Histologically proven adenocarcinoma of the prostate treated by prostatectomy with extensive lymph node dissection
- •Available pre-operative +/- PET choline
排除标准
- •Unanalyzable pre-operative MRI
结局指标
主要结局
Predicted risk of lymph-node involvement vs Briganti 2017
时间窗: immediately after the intervention/procedure/surgery
Comparison between the predicted risk of lymph node involvement based on the new algorithm and the predicted risk with the Briganti 2017
次要结局
- Seminal vesicle invasion(immediately after the intervention/procedure/surgery)
- Automatic segmentation of the index lesion(immediately after the intervention/procedure/surgery)
- Biochemical recurrence free survival(immediately after the intervention/procedure/surgery)
- Extra-prostatic disease(immediately after the intervention/procedure/surgery)
- Predicted risk of lymph-node involvement vs Briganti 2012, Briganti 2018, Briganti 2019 and MSKCC(immediately after the intervention/procedure/surgery)