Prediction of Lymph Node Invasion in Patients Operated on for Prostate Adenocarcinoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Adenocarcinoma of the Prostate
- Sponsor
- University Hospital, Brest
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- Predicted risk of lymph-node involvement vs Briganti 2017
- Last Updated
- 4 years ago
Overview
Brief Summary
Despite lymph node involvement (LNI) being one of the main prognostic factors in patients with prostate cancer (PCa), pelvic lymph node irradiation remains debated, possibly due to an insufficient selection of patients. Significant advances in LNI risk modelling have been achieved with the addition of visual interpretation of magnetic resonance imaging (MRI) data, but it is likely that quantitative analysis could further improve prediction models. In this study, the investigators aimed to develop and internally validate a novel LNI risk prediction model based on radiomic features extracted from pre-operative multimodal MRI.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Histologically proven adenocarcinoma of the prostate treated by prostatectomy with extensive lymph node dissection
- •Available pre-operative +/- PET choline
Exclusion Criteria
- •Unanalyzable pre-operative MRI
Outcomes
Primary Outcomes
Predicted risk of lymph-node involvement vs Briganti 2017
Time Frame: immediately after the intervention/procedure/surgery
Comparison between the predicted risk of lymph node involvement based on the new algorithm and the predicted risk with the Briganti 2017
Secondary Outcomes
- Seminal vesicle invasion(immediately after the intervention/procedure/surgery)
- Automatic segmentation of the index lesion(immediately after the intervention/procedure/surgery)
- Biochemical recurrence free survival(immediately after the intervention/procedure/surgery)
- Extra-prostatic disease(immediately after the intervention/procedure/surgery)
- Predicted risk of lymph-node involvement vs Briganti 2012, Briganti 2018, Briganti 2019 and MSKCC(immediately after the intervention/procedure/surgery)