MedPath

Metabolomics in Assessing the Quality of Kidney Transplants Retained on a LifePort® Perfusion Machine

Not Applicable
Completed
Conditions
Renal Transplantation
Registration Number
NCT03024229
Lead Sponsor
University Hospital, Tours
Brief Summary

When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.

Detailed Description

The quality of the renal transplant prior to transplantation is essential for the recovery of graft function in the days following transplantation and its long-term survival. When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
40
Inclusion Criteria
  • Donors aged 18 years or more in brain death or who died of cardiac arrest collected locally in Tours, associated with the major local recipients of the grafts over the same period.
Exclusion Criteria
  • Kidney transplant removed but stored in a static preservative.
  • Kidney grafts of donors aged 18 years or more, removed and not retained on a LifePort® perfusion machine.

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Primary Outcome Measures
NameTimeMethod
IGF7 days

Immediate Graft Function (IGF), defined by serum creatinine less than 250 μM / L at day 7 post-kidney transplant, without requiring dialysis of the recipient patient.

Secondary Outcome Measures
NameTimeMethod
DGF7 days

DGF Delayed graft function : Dialysis need within 7 days post-transplant

BANFF-1PRE-OPERATIONAL

Anatomo-pathological classification of the pre-implantation biopsy according to the revised Banff classification 2013

BANFF-23 months

Anatomo-pathological classification of systematic biopsy at 3 months post-transplant according to the revised Banff classification 2013

Trial Locations

Locations (2)

Urology CHRU-TOURS

🇫🇷

Tours, I&L, France

CHR-ORLEANS Service d'Urologie

🇫🇷

Orléans, Loiret, France

Urology CHRU-TOURS
🇫🇷Tours, I&L, France

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