An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy
- Registration Number
- NCT00004978
- Brief Summary
The purpose of this study is to see if it is effective to give HIV positive patients recombinant interleukin-2 (rIL-2) in addition to anti-HIV therapy. Patients will be followed over a minimum of 4 years to study the long-term effects of rIL-2 on their HIV disease progression.
Anti-HIV therapy has been very successful in treating HIV positive patients and in keeping viral load (level of HIV in the blood) low. However, anti-HIV drugs cannot completely rid the body of the virus, and the immune system is never completely restored in HIV positive patients. Doctors hope that giving patients recombinant interleukin-2 (rIL-2) in addition to their anti-HIV therapy will help improve their immune systems and keep them healthier over a longer period of time. rIL-2 is a hormone naturally produced by the body during an immune response to a microbial infection.
- Detailed Description
Much progress has been made in implementing potent antiretroviral therapy that is able to maximally suppress viral replication. However, these drug combinations do not result in viral eradication and, for many patients, virologic and immunologic control cannot be maintained. Even among patients with apparent virologic control, a "ceiling effect" seems to exist with failure of CD4 cell counts to rise on average more than 100 to 150 cells/mm\^3, at least during the first 2 years of therapy. The incomplete recovery of immune function after initiation of therapy remains an obstacle in the management of HIV. Preservation of immune function by direct expansion of CD4 lymphocytes with rIL-2 could represent a significant additional treatment strategy. It also has been speculated recently that rIL-2 in combination with potent antiretroviral therapy may be a useful approach for purging HIV from the latently infected CD4 cells. It is hoped that intervention with rIL-2 therapy in combination with antiretroviral therapy at an early stage of HIV infection can prevent CD4 T-cell depletion and result in fewer AIDS-defining illnesses than with antiretroviral therapy alone.
Patients are randomized to receive subcutaneous (SC) rIL-2 therapy or no rIL-2 therapy. All patients must be taking a regimen of combination antiretroviral treatment, with the choice of therapy at the discretion of the treating clinician. Antiretroviral medications are not provided by this study. Recombinant IL-2 is given SC for 5 consecutive days every 8 weeks for at least 3 cycles unless toxicities or other contraindications develop. After the first three cycles, additional cycles are given at the discretion of each patient's physician, with a general goal of maintaining the patient's CD4 cell count at twice the baseline level or at 1,000 cells/mm\^3 or above for as long as possible. Patients in the no rIL-2 group receive no injections. Patients in both treatment groups are seen every 4 months for follow-up data collection to monitor viral load and CD4 cell counts. All patients are followed for a minimum of 4 years. During the trial, patients in the no SC rIL-2 group are not given rIL-2 at any point. However, at the end of the study, if rIL-2 is found to be effective in reducing the rate of disease progression \[AS PER AMENDMENT 12/15/00: (new and recurrent events)\], including death, all patients are offered rIL-2.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 4150
- HIV positive
- Have a CD4 cell count of 300 cells/mm3 or more within 45 days of study entry
- Are on combination anti-HIV therapy or are beginning anti-HIV therapy at the time of study entry
- Are at least 18 years old
- Have received IL-2 before
- Have cancer requiring chemotherapy
- Have evidence of active clinical disease within the past year for any AIDS-defining illness or certain other conditions such as herpes zoster or Chagas disease. (This study has been changed. Previously, patients were ineligible if they had a history of any AIDS-defining illness or certain other conditions.)
- Have used certain medications, such as corticosteroids or drugs affecting the immune system, in the 45 days before study entry
- Have a nervous system disorder requiring antiseizure medication
- Have an autoimmune or inflammatory disease such as inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis), psoriasis, optic neuritis, or any autoimmune/inflammatory diseases with potentially life-threatening complications
- Are pregnant or breastfeeding
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description rIL-2 Recombinant interleukin-2 (rIL-2) Recombinant interleukin-2 (rIL-2) therapy used with combination anti-HIV medication of choice.
- Primary Outcome Measures
Name Time Method New or Recurrent HIV Disease Progression Event Including Death from randomization through study end - median of 7.6 years follow-up Participants who die or experience at least one: any CDC Category C 1993 AIDS-defining events or one of the following: invasive aspergillosis, bartonellosis, Chagas disease, Herpes zoster, visceral Leishmaniasis, Hodgkin's lymphoma, non-Hodgkin's lymphoma (all cell types), microsporidiosis, nocardiosis, disseminated Penicillium marneffii, extrapulmonary Pneumocystis carinii, and Rhodococcus equi disease
- Secondary Outcome Measures
Name Time Method New or Recurrent Serious HIV Disease Progression Event Including Death from randomization through study end - median of 7.6 years follow-up Patients with at least one: progressive multifocal leukoencephalopathy, lymphoma, visceral Kaposi's sarcoma, AIDS dementia complex, toxoplasmosis, histoplasmosis, cryptococcosis, Mycobacterium avium complex, wasting syndrome, and cytomegalovirus disease.
Number of Participants Who Died From Any Cause from randomization through study end - median of 7.6 years follow-up Participants With a New Disease Progression Event or Death from randomization through 15 November 2008 - median of 7.6 years follow-up Includes first new episode of: CDC Category C 1993 AIDS-defining events plus invasive aspergillosis, bartonellosis, Chagas disease, Herpes zoster, visceral Leishmaniasis, Hodgkin's lymphoma, non-Hodgkin's lymphoma (all cell types), microsporidiosis, nocardiosis, disseminated Penicillium marneffii, extrapulmonary Pneumocystis carinii, and Rhodococcus equi disease
Absolute CD4 Cell Counts Averaged Throughout Followup from randomization through study end - median of 7.6 years follow-up Average of all available CD4+ cell counts measured at follow-up visits
Plasma HIV RNA Levels From randomization through study end - median of 7.6 years follow-up log10 HIV-RNA averaged throughout follow-up
Number of Participants With Changes in Anti-retroviral Treatment (ART) From randomization through study end - median of 7.6 years follow-up Number of participants who changed ART at least once during the study period.
Grade 4 Signs and Symptoms From randomization through study end - median of 7.6 years follow-up Participants with at least one grade 4 sign or symptom (except those limited to a laboratory measurement), other than AIDS-defining conditions. Events were graded according to a standardized toxicity table. Events not specifically contained in the toxicity table were considered Grade 4 if they resulted in extreme limitation in activity or required significant medical intervention/therapy, hospitalization or hospice care. Grade 4 events by type are given under the adverse events section.
Pattern of Use of Prophylaxis for Opportunistic Infections last followup visit - median of 7.6 years follow-up Number of participants using pneumocystis pneumonia (PCP) prophylaxis at the last attended followup visit.
Hepatic, Metabolic, and Cardiac Conditions From randomization through study end - median of 7.6 years follow-up Number of participants experiencing a "serious non-AIDS" event defined as first serious cardiovascular, renal, or hepatic event, or non-AIDS malignancy.
Trial Locations
- Locations (248)
Cathedral Healthcare System, St. Michael's Med. Ctr. CRS
🇺🇸Newark, New Jersey, United States
The Early Intervention Program at Kennedy Hosp. CRS
🇺🇸Voorhees, New Jersey, United States
Toronto Gen. Hosp. Infectious Diseases CRS
🇨🇦Toronto, Ontario, Canada
Klein & Slotten Medical Associates CRS
🇺🇸Chicago, Illinois, United States
Lakeshore Infectious Disease Associates CRS
🇺🇸Chicago, Illinois, United States
Miami VAMC CRS
🇺🇸Miami, Florida, United States
Univ. of Miami, Infectious Diseases Clinical Research Unit CRS
🇺🇸Miami, Florida, United States
Funcei Crs
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Hosp. de Clinicas Jose de San Martin, Div. Infectologia CRS
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Hospital Nacional Professor Alejandro Posadas CRS
🇦🇷El Palomar, Buenos Aires, Argentina
Hosp. Italiano de Buenos Aires, Infectious Diseases Section CRS
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Hosp. de Santa Maria, Servico de Doencas Infecciosas CRS
🇵🇹Lisboa, Portugal
Canberra Hosp., Canberra Sexual Health Clinic CRS
🇦🇺Woden, Australian Capital Territory, Australia
Wojewodzki Szpital Zakazny CRS
🇵🇱Warsaw, Poland
Hospital de Cascais, HDDI, Departamento Medicina Interna CRS
🇵🇹Cascais, Portugal
Hosp. de Egas Moniz, Servicio de Infecciologia e Medicina Tropical CRS
🇵🇹Lisboa, Portugal
Chulalongkorn Univ. Hosp., HIV-NAT Research Collaboration CRS
🇹🇭Bangkok, Ratchathewi, Thailand
Khon Kaen Univ., Srinagarind Hosp., Div. of Infectious Diseases & Tropical Medicine, Dept. of Medici
🇹🇭Khon Kaen, Thailand
Royal Victoria Hosp. Dept. of Genitourinary Medicine CRS
🇬🇧Belfast, Northern Ireland, United Kingdom
Western Gen. Hosp., Regional Infectious Diseases Unit CRS
🇬🇧Edinburgh, Scotland, United Kingdom
Positive Health Practice West/ Dr. Steve Deeks CRS
🇺🇸San Francisco, California, United States
UCSF PHP, Gen. Internal Medicine Practice CRS
🇺🇸San Francisco, California, United States
Abbott Northwestern Hosp., Clinic 42 CRS
🇺🇸Minneapolis, Minnesota, United States
Atlanta VAMC CRS
🇺🇸Decatur, Georgia, United States
St. John Hosp. & Med. Ctr., Infectious Diseases Dept. CRS
🇺🇸Grosse Pointe Woods, Michigan, United States
Cooper Univ. Hosp. CRS
🇺🇸Camden, New Jersey, United States
William Beaumont Hosp., Infectious Disease Research CRS
🇺🇸Royal Oak, Michigan, United States
Raritan Bay Med. Ctr., Perth Amboy Division CRS
🇺🇸Perth Amboy, New Jersey, United States
North Side Family Medicine CRS
🇺🇸Chicago, Illinois, United States
St. Vincent Hosp. & Med. Ctr. CRS
🇺🇸New York, New York, United States
New Jersey Community Research Initiative, Jeffrey Bomser Clinic CRS
🇺🇸Newark, New Jersey, United States
Univ. of Illinois Family Ctr. for Infectious Disease CRS
🇺🇸Chicago, Illinois, United States
Northwestern Memorial Physicians Group CRS
🇺🇸Chicago, Illinois, United States
Jacobi Med. Ctr., Ambulatory Care Pavillion CRS
🇺🇸Bronx, New York, United States
Hosp. Central, Immunology Dept. CRS
🇦🇷Mendoza, Argentina
Univ. of Tokyo, Research Hosp. of the Institute of Medical Science CRS
🇯🇵Tokyo, Japan
St. Elisabeth Ziekenhuis CRS
🇳🇱Tilburg, Netherlands
Civili di Brescia, 1st Division of Infectious Diseases CRS
🇮🇹Brescia, Italy
Ospedale S. Maria Annunziata, U.O. Malattie Infettive CRS
🇮🇹Firenze, Italy
Rambam Med. Ctr., Immunology, Allergy & AIDS Institute, B. Rappaport Faculty of Medicine, Technion
🇮🇱Haifa, Israel
Kaplan Med. Ctr., Ben Ari Institute of Clinical Immunology CRS
🇮🇱Rehovot, Israel
Hopital Cochin, Service de Medecine Interne 2 CRS
🇫🇷Paris, France
Univ. Hosp. Charite, Dept of Infectious Diseases CRS
🇩🇪Berlin, Germany
Ctr. for HIV & Hepatogastroenterology, HIV Specialised Practice (Private Practice) CRS
🇩🇪Duesseldorf, Germany
Medizinische Universitaetsklinik - Bonn, Immunologische Ambulanz CRS
🇩🇪Bonn, Germany
Tel Aviv Sourasky Med. Ctr., Clinical Immunology Unit and AIDS Ctr. CRS
🇮🇱Tel Aviv, Israel
Hopital Saint-Antoine, Service de Maladies Infectieuses CRS
🇫🇷Paris, France
Hopital Tenon, Service de Maladies Infectieuses et Tropicales CRS
🇫🇷Paris, France
IPM Study Ctr. (Hamburg) CRS
🇩🇪Hamburg, Germany
Klinik I fur Innere Medizin der Universitat zu Koln, Studienburo fur Infektiologie u. HIV CRS
🇩🇪Koln, Germany
Klinikum Innenstadt, Infektionsambulanz und Tagesklinik CRS
🇩🇪Munchen, Germany
Hopital de La Salpetriere, Service de Medecine Interne CRS
🇫🇷Paris, France
Hopital Necker, Service des Maladies Infectieuses CRS
🇫🇷Paris, France
Hopital Europeen Georges Pompidou, Service d'Immunologie Clinique CRS
🇫🇷Paris, France
Denver Public Health CRS
🇺🇸Denver, Colorado, United States
Univ. of Colorado Health Science Ctr. CRS
🇺🇸Denver, Colorado, United States
Henry Ford Hosp. CRS
🇺🇸Detroit, Michigan, United States
Wayne State Univ. CRS
🇺🇸Detroit, Michigan, United States
The Research & Education Group-Portland CRS
🇺🇸Portland, Oregon, United States
Providence Portland Med. Ctr., Ambulatory Care and Education Ctr. CRS
🇺🇸Portland, Oregon, United States
San Matteo Hospital - University of Pavia, Division of Infectious and Tropical Diseases CRS
🇮🇹Pavia, Italy
Universita La Sapienza, Clinica Universita La Sapienza CRS
🇮🇹Roma, Italy
Mayo Clinic INSIGHT CRS
🇺🇸Rochester, Minnesota, United States
C.H.U. Bichat - Claude Bernard Service des Maladies Infectieuses et Tropicales CRS
🇫🇷Paris, France
CHRU de Strasbourg (France) CRS
🇫🇷Strasbourg, France
Hopital Foch, Service de Medecine Interne CRS
🇫🇷Suresenes, France
Univ. of Wuerzburg, Medizinische Poliklinik, Schwerpunkt Hepatologie/Infektiologie CRS
🇩🇪Wuerzburg, Germany
NIH Clinical Ctr., NIAID HIV Clinic CRS
🇺🇸Bethesda, Maryland, United States
National Naval Med. Ctr., Infectious Diseases Special Immunology Clinic CRS
🇺🇸Bethesda, Maryland, United States
VA Greater Los Angeles Healthcare System, Infectious Diseases Section CRS
🇺🇸Los Angeles, California, United States
Dr. Robert Scott Med. Practice CRS
🇺🇸Oakland, California, United States
East Bay AIDS Ctr. CRS
🇺🇸Oakland, California, United States
Dr. Shawn Hassler Med. Practice CRS
🇺🇸San Francisco, California, United States
Positive Health Program Clinic (San Francisco Gen. Hosp.) CRS
🇺🇸San Francisco, California, United States
Dr. William Owen Med. Practice CRS
🇺🇸San Francisco, California, United States
Dr. Martin Mass Med. Practice CRS
🇺🇸San Francisco, California, United States
San Francisco VAMC, Infectious Diseases Clinic CRS
🇺🇸San Francisco, California, United States
Castro-Mission Health Ctr. CRS
🇺🇸San Francisco, California, United States
Dr. Virginia Cafaro Med. Practice CRS
🇺🇸San Francisco, California, United States
Denver Infectious Diseases Consultants CRS
🇺🇸Denver, Colorado, United States
Whitman-Walker Clinic CRS
🇺🇸Washington, District of Columbia, United States
George Washington Univ. Med. Ctr. Infectious Diseases - Clinical Trials Unit CRS
🇺🇸Washington, District of Columbia, United States
Walter Reed Army Med. Ctr., Infectious Disease Clinic CRS
🇺🇸Washington, District of Columbia, United States
Dr. Timothy A. Price Med. Practice CRS
🇺🇸Washington, District of Columbia, United States
Washington DC VAMC, Washington Regional AIDS Program, Infectious Diseases CRS
🇺🇸Washington, District of Columbia, United States
Emory Univ. Crawford Long Hosp. CRS
🇺🇸Atlanta, Georgia, United States
Jesse Brown VAMC CRS
🇺🇸Chicago, Illinois, United States
ARCA, Central Clinc CRS
🇺🇸Atlanta, Georgia, United States
ID Care Inc. - Hillsborough CRS
🇺🇸Hillsborough, New Jersey, United States
Jersey Shore Univ. Med. Ctr. CRS
🇺🇸Neptune, New Jersey, United States
Infectious Disease Specialists of N.J., North Jersey Community Research Initiative CRS
🇺🇸Union, New Jersey, United States
Bronx VAMC CRS
🇺🇸Bronx, New York, United States
Harlem Hospital Ctr./Columbia University CRS (Gordin CTU)
🇺🇸New York, New York, United States
Oregon Health & Sciences Univ. Internal Medicine (L-475) CRS
🇺🇸Portland, Oregon, United States
Multnomah County Health Dept., HIV Health Services Ctr. CRS
🇺🇸Portland, Oregon, United States
Kaiser Immune Deficiency Clinic of Portland CRS
🇺🇸Portland, Oregon, United States
Salem Hosp. CRS
🇺🇸Salem, Oregon, United States
Legacy Clinic Emanuel CRS
🇺🇸Portland, Oregon, United States
Kaiser Permanente Lancaster Clinic CRS
🇺🇸Salem, Oregon, United States
Thomas Street Clinic CRS
🇺🇸Houston, Texas, United States
Univ. Clinical Research Ctr., Memorial Hermann Hosp. CRS
🇺🇸Houston, Texas, United States
Michael E. DeBakey VAMC CRS
🇺🇸Houston, Texas, United States
Northwest Clinic CRS
🇺🇸Houston, Texas, United States
Legacy Community Health Services, Inc., Montrose Clinic, Inc.
🇺🇸Houston, Texas, United States
South Texas Veterans Health Care System, Immunosuppression Clinic CRS
🇺🇸San Antonio, Texas, United States
Hanover Med. Park (Mechanicsville, VA) CRS
🇺🇸Mechanicsville, Virginia, United States
Naval Med. Ctr. Portsmouth CRS
🇺🇸Portsmouth, Virginia, United States
Hosp. Gen. de Agudos JM Ramos Mejia, Servicio de Inmunocomprometidos CRS
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Hospital de Infecciosas F.J. Muniz CRS
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Hosp. Gen. de Agudos Juan A. Fernandez CRS
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Hosp. Gen. de Agudos 'Teodoro Alvarez' CRS
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Hospital Interzonal de Agudos Oscar Alende, Sala de Infectologia CRS
🇦🇷Mar del Plata, Buenos Aires, Argentina
Caici Crs
🇦🇷Rosario, Provincia De Santa Fe, Argentina
Hosp. Rawson CRS
🇦🇷Cordoba, Argentina
Hosp. Interzonal de Agudos San Juan de Dios CRS
🇦🇷La Plata, Argentina
Interchange General Practice CRS
🇦🇺Canberra, Australian Capital Territory, Australia
Burwood Road Gen. Practice CRS
🇦🇺Burwood, New South Wales, Australia
St. Vincent's Hospital CRS
🇦🇺Darlinghurst, New South Wales, Australia
Taylor Square Private Clinic CRS
🇦🇺Darlinghurst, New South Wales, Australia
John Hunter Hosp., Immunology & Infectious Diseases Unit CRS
🇦🇺Newcastle, New South Wales, Australia
Albion Street Ctr. CRS
🇦🇺Surry Hills, New South Wales, Australia
Queensland Health - AIDS Med. Unit CRS
🇦🇺Brisbane, Queensland, Australia
407 Doctors CRS
🇦🇺Surry Hills, New South Wales, Australia
Cairns Base Hosp., Sexual Health Services CRS
🇦🇺Cairns, Queensland, Australia
Gladstone Road Medical Ctr. CRS
🇦🇺Highgate Hill, Queensland, Australia
The Care & Prevention Programme CRS
🇦🇺Adelaide, South Australia, Australia
Royal Adelaide Hosp. CRS
🇦🇺Adelaide, South Australia, Australia
Carlton Clinic CRS
🇦🇺Carlton, Victoria, Australia
Nambour Gen. Hosp. CRS
🇦🇺Nambour, Queensland, Australia
The Alfred Hosp., Clinical Research - Infectious Diseases Unit CRS
🇦🇺Melbourne, Victoria, Australia
Prahran Market Clinic CRS
🇦🇺Melbourne, Victoria, Australia
Northcote Clinic CRS
🇦🇺Northcote, Victoria, Australia
Royal Melbourne Hosp., Victorian Infectious Diseases Service CRS
🇦🇺Parkville, Victoria, Australia
The Ctr. Clinic INSIGHT CRS
🇦🇺St. Kilda, Victoria, Australia
Royal Perth Hospital CRS
🇦🇺Perth, Western Australia, Australia
Gold Coast Sexual Health Clinic CRS
🇦🇺Miami, Queensland, Australia
Univ. of Vienna Med. School, Div. of Allergy, Immunology & Infectious Diseases - Sued B CRS
🇦🇹Vienna, Austria
SMZ Baumgartner Hoehe, Immunambulanz Pavillion Wienerwald Parterre CRS
🇦🇹Wien, Austria
Ctr. Hospitalier Universitaire, St Pierre, Div. of Infectious Diseases (PL5) CRS
🇧🇪Bruxelles, Belgium
Centro de Referencia e Treinamento em DST/AIDS - Sao Paulo CRS
🇧🇷Vila Mariana, Sao Paulo, Brazil
Instituto de Infectologia Emilio Ribas CRS
🇧🇷Sao Paulo, Brazil
Universidade Federal de Sao Paulo,IDIPA-Instituto Paulista de Doencas Infecciosas e Parasitarias CRS
🇧🇷Sao Paulo, Brazil
Cool Aid Community Health Ctr. CRS
🇨🇦Victoria, British Columbia, Canada
Univ. of Alberta Hosp., Clinical Research Office CRS
🇨🇦Edmonton, Alberta, Canada
Q.E. II Health Sciences Ctr., Captial District Authority, Victoria Gen. Hosp. CRS
🇨🇦Halifax, Nova Scotia, Canada
Ottawa Hosp., Gen. Campus CRS
🇨🇦Ottawa, Ontario, Canada
St. Joseph's Health Ctr. of London, HIV Care Programme CRS
🇨🇦London, Ontario, Canada
CHUS - Hopital Fleurimont, Centre de Recherche Clinique CRS
🇨🇦Fleurimont, Quebec, Canada
Hopital Maisonneuve-Rosemont, Dept. de Microbiologie CRS
🇨🇦Montreal, Quebec, Canada
Odense Univ. Hosp., Med. Dept. C CRS
🇩🇰Odense, Denmark
CHUM - Campus Notre-Dame CRS
🇨🇦Montreal, Quebec, Canada
Royal Victoria Hosp., Montreal Chest Institute CRS
🇨🇦Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Quebec - CHUL, Centre de Recherche en Indectiologie CRS
🇨🇦Sainte-Foy, Quebec, Canada
Aalborg Hosp., Dept. of Infectious Diseases CRS
🇩🇰Aalborg, Denmark
Royal Univ. Hosp. CRS
🇨🇦Saskatoon, Saskatchewan, Canada
Skejby Sygehus, Department of Infectious Diseases Q (ambulatoriet) CRS
🇩🇰Aarhus, Denmark
Rigshospitalet, Department of Infectious Diseases, M5112 CRS
🇩🇰Copenhagen, Denmark
Hvidovre Univ. Hosp., Dept. of Infectious Diseases CRS
🇩🇰Hvidovre, Denmark
Centre Hospitalier de la Region Annecienne, Service des Maladie Infectieuses CRS
🇫🇷Cedex, Pringy, France
CHRU d'Angers, Service de Maladies Infectieuses CRS
🇫🇷Angers, France
Hopital Saint-Jacques, Service des Maladies Infectieuses et Tropicales CRS
🇫🇷Besancon, France
Hopital Antoine Beclere Service d'Immunologie Clinique CRS
🇫🇷Clamart, France
Hopital Avicenne, Service de Medecine B CRS
🇫🇷Bobigny, France
Hopital Louis Mourier, Service de Medecine Interne CRS
🇫🇷Colombes, France
Hopital Henri Mondor, Immunopathologie Clinique CRS
🇫🇷Creteil, France
Hopital Raymond Poincare - Vidal 2, Service des Maladies Infectieuses et Tropicales CRS
🇫🇷Garches, France
Hopital de la Conception, Service des Maladies Infectieuses CRS
🇫🇷Marseille, France
Hopital de Bicetre, Service de Medecine Interne CRS
🇫🇷Le Kremlin-Bicetre, France
Hopital Sainte Marguerite, CISIH Hopital de Jour CRS
🇫🇷Marseille, France
Hopital Gui de Chauliac, Service des Maladies Infectieuses et Tropicales CRS
🇫🇷Montpellier, France
Hopital de l'Archet 1, Service de Medecine Interne 2 Hematologie Clinique CRS
🇫🇷Nice, France
Ruhr-Univ., Interdiszipl. Immunolog. Ambulanz CRS
🇩🇪Bochum, Germany
Johann Wolfgang Goethe Univ. Hosp., Infektionsambulanz CRS
🇩🇪Frankfurt, Germany
Univ. Hosp. Heidelberg, Dept. of Dermatology CRS
🇩🇪Heidelberg, Germany
St. James' Hosp., Guide Clinic CRS
🇮🇪Dublin, Ireland
Civili di Brescia, Dept of Infectious & Tropical Disease, Hosp.Spedali Civili of Brescia CRS
🇮🇹Brescia, Italy
Ospedale San Raffaele, Centro San Luigi - Divisione Malattie Infettive CRS
🇮🇹Milano, Italy
Universita degli Studi di Modena e Reggio Emilia, Clinica delle Malattie Infettive e Tropicali CRS
🇮🇹Modena, Italy
Univ. of Milan, Ospedale Luigi Sacco, Institute of Infectious and Tropical Diseases CRS
🇮🇹Milano, Italy
Osaka National Hosp. AIDS Ctr., Clinical Research Institute CRS
🇯🇵Osaka, Japan
International Med. Ctr. of Japan CRS
🇯🇵Tokyo, Japan
OLVG -- locatie Prinsengracht, Dept. of Internal Medicine II CRS
🇳🇱Amsterdam, Netherlands
Academisch Medisch Centrum CRS
🇳🇱Amsterdam, Netherlands
Univ. Hosp. Ctr. of the Med. School of Casablanca, Infectious Diseases Unit CRS
🇲🇦Casablanca, Morocco
Stichting Medisch Centrum Jan van Goyen, Dept. of Internal Medicine CRS
🇳🇱Amsterdam, Netherlands
Groningen Univ. Hosp., Department of Internal Medicine CRS
🇳🇱Groningen, Netherlands
Kennemer Gasthuis, Lokatie EG CRS
🇳🇱Haarlem, Netherlands
Ulleval Hosp., Dept. of Infectious Diseases CRS
🇳🇴Oslo, Norway
Szpital Specjalistyczny, Osrodek Diagnostyki i Terapii AIDS CRS
🇵🇱Chorzow, Poland
Pomeranian Academy of Medicine (PAM), Dept. of Infectious Diseases and Hepatology CRS
🇵🇱Szczecin, Poland
Wroclaw Univ., School of Med., Dept. of Infectious Diseases, Liver Diseases and AIDS CRS
🇵🇱Wroclaw, Poland
Tan Tock Seng Hosp., Infectious Diseases Research Ctr. CRS
🇸🇬Singapore, Singapore
Hosp. Donostia CRS
🇪🇸San Sebastian, Guipuzcoa, Spain
Hosp. Juan Canalejo, Dept. of Internal Medicine CRS
🇪🇸A Coruna, Spain
Hosp. Clinico de Barcelona CRS
🇪🇸Barcelona, Spain
Hosp. Universitario Gregorio Maranion, Microbiology & Infectious Diseases Unit CRS
🇪🇸Madrid, Spain
Centro de Investigacion Carlos III, Infectious Diseases Dept. CRS
🇪🇸Madrid, Spain
Hosp. Ramon y Cajal (Madrid) CRS
🇪🇸Madrid, Spain
Karolinska Univ. Hosp. Huddinge, Dept. of Infectious Diseases CRS
🇸🇪Stockholm, Sweden
Hosp. Universitario Morales Meseguer CRS
🇪🇸Murcia, Spain
Hosp. Virgen del Rocio, Infectious Diseases Service CRS
🇪🇸Sevilla, Spain
Venhalsan, Soder Hosp., Dept. of Infectious Diseases, Karolinska Univ. Hosp. CRS
🇸🇪Stockholm, Sweden
Regional Hosp. of Lugano (Sede Civico), Ospedale Civico di Lugano, Infectious Diseases Unit CRS
🇨🇭Lugano, Ticino, Switzerland
Siriraj Hosp., Mahidol Univ. INSIGHT CRS
🇹🇭Bangkok, Ratchathewi, Thailand
Chonburi Regional Hosp., Dept. of Internal Medicine CRS
🇹🇭Chonburi, Thailand
Chiang Rai Regional Hosp. INSIGHT CRS
🇹🇭Chiangrai, Thailand
Brighton & Sussex Univ. Hosp. NHS Trust, HIV Research Office CRS
🇬🇧Elm Grove, Brighton, United Kingdom
Churchill Hosp. John Warin Ward CRS
🇬🇧Headington, Oxford, United Kingdom
Heartlands Hosp. Dept. of Infection & Tropical Disease Outpatients CRS
🇬🇧Birmingham, United Kingdom
Gartnaval Gen. Hosp., Brownlee Ctr. CRS
🇬🇧Glasgow, Scotland, United Kingdom
Royal Devon & Exeter NHS Foundation Trust, Heavitree Hosp., Dept. of GU Medicine CRS
🇬🇧Exeter, United Kingdom
Leicester Royal Infirmary, Dept. of Infection & Tropical Medicine CRS
🇬🇧Leicester, United Kingdom
St. George's Hosp. Clinical Infection UnitCRS
🇬🇧London, United Kingdom
Chelsea & Westminster Hosp., St. Stephens Ctr. CRS
🇬🇧London, United Kingdom
St. Thomas' Hosp., Dept. of GU Medicine CRS
🇬🇧London, United Kingdom
King's College Hosp., Caldecot Ctr. Dept. of Sexual Health CRS
🇬🇧London, United Kingdom
St. Mary's Hosp. of London, Imperial College School of Medicine CRS
🇬🇧London, United Kingdom
St. Bartholomew's Hosp., Infection & Immunity Clinical Group CRS
🇬🇧London, United Kingdom
Royal Free Hosp., Dept. of Infection & Immunity, Ian Charleson Day Ctr. CRS
🇬🇧London, United Kingdom
Univ. College London Med. School, Ctr. for Sexual Health & HIV Research CRS
🇬🇧London, United Kingdom
Newcastle Gen. Hosp., Dept of Infection & Tropical Medicine CRS
🇬🇧Newcastle Upon Tyne, United Kingdom
Royal Hallamshire Hosp., Dept. of GU Medicine Communicable Diseases Unit CRS
🇬🇧Sheffield, United Kingdom
Edith Cavell Hosp. Dept. of Sexual Health, Clinic E CRS
🇬🇧Peterborough, United Kingdom
Hosp. Santa Creu i Sant Pau, Servicio de Medicina Interna CRS
🇪🇸Barcelona, Spain
Hosp. Severo Ochoa, Internal Medicine and Infectious Diseases CRS
🇪🇸Madrid, Spain
Hosp. Clinico San Carlos CRS
🇪🇸Madrid, Spain
St. Joseph's Hosp. & Med. Ctr. of New Jersey CRS
🇺🇸Paterson, New Jersey, United States
Dr. M. Estes Med. Practice CRS
🇺🇸Mill Valley, California, United States
ID Care - Randolph CRS
🇺🇸Randolph, New Jersey, United States
Holdsworth House Gen. Practice CRS
🇦🇺Darlinghurst, New South Wales, Australia
Hosp. Universitari Germans Trias i Pujol, HIV Unit and Retrovirology Lab. CRS
🇪🇸Barcelona, Spain
McMaster Univ. Med. Ctr. Hamiton Health Sciences, SIS Clinic CRS
🇨🇦Hamilton, Ontario, Canada
Hosp. del Mar, Internal Medicine-Infectious Diseases CRS
🇪🇸Barcelona, Spain
The HAVEN Program, Sudbury Regional Hosp., Laurentian Site CRS
🇨🇦Sudbury, Ontario, Canada
Windsor Regional Hosp., HIV Care Program CRS
🇨🇦Windsor, Ontario, Canada
Hosp. 12 de Octubre, Pabellon de Medicina Communitaria CRS
🇪🇸Madrid, Spain
Hosp. la Princesa, Internal Medicine and Infectious Diseases Service CRS
🇪🇸Madrid, Spain
Hosp. Universitario La Paz CRS
🇪🇸Madrid, Spain
Hosp. Universitario Principe de Asturias CRS
🇪🇸Madrid, Spain
Temple Univ. School of Medicine CRS
🇺🇸Philadelphia, Pennsylvania, United States
Med. Ctr. of Louisiana at New Orleans, HIV Outpatient Clinics CRS
🇺🇸New Orleans, Louisiana, United States
Tulane University Health Sciences Center, Louisiana Community AIDS Research Program(LaCARP) CRS
🇺🇸New Orleans, Louisiana, United States
New Orleans VAMC CRS
🇺🇸New Orleans, Louisiana, United States
CrossOver Health Ctr. CRS
🇺🇸Richmond, Virginia, United States
South Richmond Health Care Ctr. CRS
🇺🇸Richmond, Virginia, United States
Hunter Holmes McGuire VAMC CRS
🇺🇸Richmond, Virginia, United States
Virginia Commonwealth Univ. Medical Ctr. CRS
🇺🇸Richmond, Virginia, United States
Royal London Hosp., Ambrose King Ctr. CRS
🇬🇧London, United Kingdom