DRKS00004573招募中不适用
Predictors of outcome in heart failure with preserved ejection fraction - HFPEF
Medizinische Universität Wien, Allgemeines Krankenhaus der Stadt Wien, Universitätsklinik II für Innere Medizin , Abteilung für Kardiologie0 个研究点目标入组 350 人开始时间: 2012年12月12日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 350
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Inclusion Criteria:
- •1. Age = 18 years
- •2. written informed consent
- •3. symptoms or signs of heart failure (NYHA > I)
- •4. transthoracic echocardiography:
- •LVEF > 50 %
- •LVEDVI < 97ml/m2
- •E/E' > 15
- •15>E/e’>8 and NT-proBNP > 220pg/ml
- •5. Right heart catheter
- •PCWP = 15 mmHg +/- PAPmean = 25 mmHg
排除标准
- •Exclusion Criteria:
- •1. Inability or unwillingness to perform any of the diagnostic tests and to participate in follow-up visits
- •2. Left ventricular ejection fraction =50%
- •3. Significant valvular heart disease
- •4. Congenital heart disease
- •5. Significant coronary artery disease requiring percutaneous coronary intervention or aorto-coronary bypass surgery
- •6. Left ventricular diastolic dysfunction without symptoms or signs of heart failure, such as presence or history of dyspnea at rest, fluid retention, jugular vein distension
- •7. Severe chronic renal insufficiency (GFR <30 ml/min)
- •8. Pregnancy
- •9. Bronchial asthma or COPD with Forced Expiratory Volume in one second (FEV1) <60% predicted
- •10. Restrictive lung disease with Total Lung Capacity <60% predicted
- •11. Severe congenital abnormalities of the lungs, thorax, or diaphragm
- •12. Abnormalities in blood gases (measured capillary or arterial): SaO2 <88% or PaO2 <55 mmHg
研究者
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