ACTRN12615000220561
Not yet recruiting
Phase 2
A randomized controlled trial of the efficacy of intravenous tenecteplase versus alteplase within 4.5 hours of ischemic stroke onset in patients undergoing endovascular therapy, utilizing dual target vessel occlusion and penumbral mismatch imaging selection
euroscience Trials Australia0 sites64 target enrollmentMarch 9, 2015
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- euroscience Trials Australia
- Enrollment
- 64
- Status
- Not yet recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patients presenting with acute ischemic stroke eligible using
- •standard criteria to receive IV thrombolysis within 4\.5 hours
- •of stroke onset
- •2\. Patient is 18 years or older
- •3\. Intra\-arterial clot retrieval treatment can commence (groin
- •puncture) within 6 hours of stroke onset.
- •Imaging inclusion criteria
- •Dual target:
- •5\. Arterial occlusion on CT angiography of the internal carotid, middle cerebral (M1/M2 segments) or basilar artery
- •6\. Mismatch (only applies to anterior circulation)\- Using CT perfusion with a Tmax \>6 second delay perfusion volume and CT\-rCBF ischemic core volume.
Exclusion Criteria
- •1\. Intracranial hemorrhage (ICH) identified by CT
- •2\. Rapidly improving symptoms at the discretion of the
- •investigator
- •3\. Pre\-stroke mRS score of \>\=4 (indicating previous disability)
- •4\. Hypodensity in \>1/3 MCA territory or equivalent proportion
- •of basilar artery territory on non\-contrast CT
- •5\. Contra indication to imaging with contrast agents
- •6\. Any terminal illness such that patient would not be expected
- •to survive more than 1 year
- •7\. Any condition that, in the judgment of the investigator could
Outcomes
Primary Outcomes
Not specified
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