Genetics, Imaging and Artificial Intelligence for Precision Care in Cardiomyopathy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- Incidence of genetic variants
研究概览
简要总结
Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses.
Finding new ways to diagnose and treat cardiomyopathies could improve the health and well-being of patients with these conditions.
This study will collect data from individuals with cardiomyopathy or related heart muscle disease, or with a possible genetic predisposition to cardiomyopathy, and follow them over time to observe the progress of their heart and health. This study will collect DNA, blood samples, and detailed clinical & lifestyle information at the start of the study, and data collected during routine healthcare visits over time.
- learn what causes cardiomyopathy, and therefore how to treat it
- understand why cardiomyopathy progresses differently in different people, to improve the ability to recognise who will benefit from different treatments at different times
The investigators will collaborate with other centres internationally to collect a large of group of participants with similar cardiomyopathies, providing power to identify new pathways that cause disease and ways of predicting which participants are at risk of having more severe disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults with the capacity to consent Children with parental/guardian consent Male and Female
- •Meeting the following criteria:
- •Patients with a confirmed diagnosis of cardiomyopathy or related condition
- •Patients with a family member with cardiomyopathy, or a related condition
- •Patients with a genetic variant that may predispose to cardiomyopathy, or a related condition
排除标准
- •Patients without the capacity to provide informed consent
结局指标
主要结局
Incidence of genetic variants
时间窗: 5 years
Rare and common genetic variants in people with cardiomyopathy
The incidence of major adverse cardiovascular events over 5 years
时间窗: 5 years
The incidence of major adverse cardiovascular events over 5 years, defined as:- 1. Cardiovascular death 2. Major arrhythmic events (ventricular fibrillation, unstable sustained ventricular tachycardia, appropriate implantable cardioverter-defibrillator delivered shock, and aborted sudden cardiac death) 3. Major heart failure events (heart transplantation, left ventricular assist device implantation, unplanned heart failure hospitalisation)
次要结局
未报告次要终点