Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- Heart transplantation confirmed by medical record
研究概览
简要总结
Genetic mutations has been proved to be associated wth the onset of cardiomyopathy. In the present study, we intend to identify new related variants or genes. From March, 2003 to November, 2017, patients diagnosed as cardiomyopathy were consecutively recruited, and their sampled were drawn from peripheral blood. Paired control group were also enrolled. The whole exome sequencing was used to find out the variants associated with the onset of cardiomyopathy and its prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •· Patients diagnosed as cardiomyopathy according to the definition of American Heart Association
排除标准
- •Uncontrolled hypertension significant valvular disease
- •Mild ischemic heart disease
- •Significant systemic infection
- •Thyroid-induced cardiomyopathy
- •Excessive alcohol consumption
- •Precious cancer treatment including irradiation
- •Refusal to participate in the study
结局指标
主要结局
Heart transplantation confirmed by medical record
时间窗: up to 24 months
Heart transplantation within 24 months
Cardiovascular death confirmed by death comfirmation or interview with the relatives
时间窗: up to 24 months
Death from cardiovascular causes and any unknown death unless there was another certain cause
次要结局
- All cause death confirmed by death comfirmation or interview with the relatives(up to 24 months)
- Heart failure recurring confirmed by medical record(up to 24 months)