Intervention Strategy in Chronic Obstructive Pulmonary Disease With Anxiety and Depression

Not Applicable

• Conditions: COPD; Anxiety; Depression
• Interventions: Behavioral: Cognitive Behavioral Therapy; Behavioral: Pulmonary Rehabilitation Therapy; Behavioral: Combined Therapy

• Registration Number: NCT03187249
• Lead Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital

Brief Summary

Anxiety and depression have negative effect on outcomes of chronic obstructive pulmonary disease (COPD). Intervention strategy including behavioral-cognitive therapy and pulmonary rehabilitation are promising in improving life quality, disease symptom and outcomes. But there's not standard algorithm in China so far. The study aims to compare the effectiveness of these interventions and develop an intervention algorithm of anxiety and depression in COPD.

Detailed Description

Not available

Study Timeline

• Status Verified: 2017-06
• Study First Submitted: 2017-06-13
• Study First Submitted QC: 2017-06-13
• Last Update Submitted: 2017-06-13
• Study First Posted: 2017-06-14
• Last Update Posted: 2017-06-14
• Study Start: 2017-06-15
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Stable COPD patients with mild or moderate anxiety and depression

Exclusion Criteria

• Patients with bronchial asthma or other severe pulmonary diseases or having received pulmonary surgery in 6 months
• Patients with tumor history during past 5 years
• Patients with COPD exacerbations during past 4 weeks
• Participants in clinical trials
• Patients in pregnancy or breastfeeding
• Patients unable to complete questionaire independently
• Patients older than 80 years old
• Patients receiving long-term domiciliary oxygen therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cognitive Behavioral Therapy	Cognitive Behavioral Therapy	receive cognitive-behavioral therapy for 12 weeks
Pulmonary Rehabilitation Therapy	Pulmonary Rehabilitation Therapy	receive pulmonary rehabilitation therapy for 12 weeks
Combined Therapy	Combined Therapy	receive both cognitive-behavioral therapy and pulmonary rehabilitation therapy for 12 weeks

Primary Outcome Measures

Name	Time	Method
Hospital Anxiety and Depression Scale	12 weeks	total score

Secondary Outcome Measures

Name	Time	Method
moderate and severe COPD exacerbations	3 years	total times
modified British medical research council score	3 years	total score
COPD assessment test score	3 years	total score

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, Beijing, China