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临床试验/NCT03409055
NCT03409055已完成不适用

Pleural Effusions Are Associated With Adverse Outcomes After Cardiac Surgery

Charite University, Berlin, Germany1 个研究点 分布在 1 个国家目标入组 11,198 人开始时间: 2006年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
11,198
试验地点
1
主要终点
hospital stay

研究概览

简要总结

Pleural effusions occur commonly in patients recovering from cardiac surgery, however, the impact on outcomes is not well characterized. The purpose of this study is to characterize the outcomes of cardiac surgery patients with pleural effusions.

All patients undergoing cardiac surgery between 2006 and 2019 were included in this observational, cross-sectional analysis using propensity matching.

详细描述

Pleural effusions are common in patients recovering from cardiac surgery. Symptomatic patients with pleural effusions complain of shortness of breath, cough, chest pain and are more hypoxic and tachypneic. Clinically significant effusions can slow recovery in the hospital and beyond, and are a critical source of hospital readmissions after discharge. It is not well characterized how this impacts hospital outcomes. Further it is unknown if the effusions themselves are associated with impaired outcomes, or if pleural effusions simply arise in more complicated, older patients, thus suggesting the impaired outcomes are the result of coexisting morbidities. To better understand the impact of this complication and to address the question mentioned before, this study was carried out to determine the clinical and economic outcomes of pleural effusions in propensity-matched patients during early recovery from cardiac surgery. To compare patient groups with and without pleural effusion, the following baseline characteristics were used: e.g. age, sex, body-mass-index, priority of surgery, type of surgery, duration of surgery, APACHE II Score of patients on admission in the ICU.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • In-patients of the Charité Universitätsmedizin Berlin
  • at least 18 years old
  • female or male sex
  • cardiosurgical intervention (OPS 5.35 and 5.36) between 01/06 and 12/19
  • post-operative monitoring in the intensive care unit

排除标准

  • previous cardiosurgical interventions during the same hospital stay
  • incomplete documentation.

结局指标

主要结局

hospital stay

时间窗: an average of 30 days

Length of hospital stay

mortality

时间窗: an average of 30 days

In-Hospital mortality

次要结局

  • Need of drainage(an average of 30 days)
  • extubation(an average of 15 hours)
  • ICU stay(an average of 15 days)
  • renal replacement(an average of 30 days)
  • transfusions(an average of 30 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Felix Balzer

Prof. Dr. med. Dr. rer. nat., MSc

Charite University, Berlin, Germany

研究点 (1)

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