Comparison of Four Different Recruitment Maneuvers in Patients After Coronary Surgery

Not Applicable

Completed

• Conditions: Hypoxemia; Recruitment
• Interventions: Procedure: Alveolar recruitment

• Registration Number: NCT01457651
• Lead Sponsor: Northern State Medical University

Brief Summary

The risk of respiratory failure after cardiac surgery is high, and it may result in many complications. The maneuver of alveolar recruitment may improve the oxygen transport in the human organism. The investigators compare three different types of alveolar recruitment in patient after cardiac surgery, to reveal which one is better.

Detailed Description

The study compares three different approaches to alveolar recruitment maneuvers in the immediate postoperative period after off-pump coronary bypass grafting.

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2011-10-20
• Study First Submitted QC: 2011-10-21
• Study First Posted: 2011-10-24
• Primary Completion: 2011-12
• Study Completion: 2012-01
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-24
• Last Update Posted: 2013-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• Age between 18 and 75
• Off-pump coronary artery bypass grafting
• Possibility to discontinue respiratory support in the first day after intervention

Exclusion Criteria

• Signs of ARDS
• COPD in decompensation phase
• Requirement for inotropic support(epinephrine >0,1 mcg/kg/hr)
• Bronchiectases
• Pregnancy
• Morbid obesity
• Aortic aneurism
• AMI in previous month

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Recruitment 15x300	Alveolar recruitment	Recruitment by increase in airway PEEP up to 15 cm H2O for 300 sec
No recruitment	Alveolar recruitment	No recruitment is performed: standard respiratory support.
Recruitment PEAK40	Alveolar recruitment	Increase in peak airway pressure up to 40 cm H2O during tidal ventilation
Recruitment 40x40	Alveolar recruitment	The group where recruitment is performed by increase in airway pressure up to 40 cm H2O for 40 seconds

Primary Outcome Measures

Name	Time	Method
Respiratory support	24 hrs	The duration of the postoperative respiratory support

Secondary Outcome Measures

Name	Time	Method
The incidence of postoperative atelectasis	24 hrs	Incidence of atelectases during 24 hrs
Incidence of reintubation	24 Hrs
Oxygenation	12 hrs after extubation	Changes in PaO2/FiO2 ratio
Length of ICU and hospital stay	28 Days	Length of ICU and hospital stay

Trial Locations

Locations (1)

City hospital # 1; 🇷🇺 Arkhangelsk, Arkhangelsk region, Russian Federation