Antiemetic Effect of the Addition of Ondansetron to the Morphine Solution in Patient-Controlled Analgesia (PCA)
Not Applicable
Completed
- Conditions
- Postoperative Nausea and Vomiting
- Registration Number
- NCT00199329
- Lead Sponsor
- Khon Kaen University
- Brief Summary
PCA morphine always introduces nausea and vomiting during the postoperative period. Ondansetron can reduce PONV (postoperative nausea vomiting). We, the researchers at Khon Kaen University, are trying to add ondansetron in PCA morphine. Patients receive a small dose of ondansetron when they request morphine.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
- Age between 15-60 years old
Exclusion Criteria
- History of motion sickness, smoking
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method PONV 24 hr
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie ondansetron's antiemetic effects in PCA morphine for postoperative nausea and vomiting?
How does the addition of ondansetron to PCA morphine compare to standard antiemetic protocols in reducing PONV incidence?
Are there specific biomarkers that predict enhanced response to ondansetron in PCA morphine for postoperative nausea and vomiting?
What are the potential adverse events associated with ondansetron PCA morphine combinations and their management strategies?
What other 5-HT3 receptor antagonists or combination therapies are being explored for postoperative nausea and vomiting alongside morphine?
Trial Locations
- Locations (1)
Khon Kaen university, Srinagarind Hospital
🇹🇭Muang, Khon Kaen, Thailand
Khon Kaen university, Srinagarind Hospital🇹🇭Muang, Khon Kaen, Thailand