Chronic disease in Immune Thrombocytopenia of Childhood

Completed

• Conditions: immune thrombocytopenic purpura; platelet destruction by antibodies; 10035534; 10003816

• Registration Number: NL-OMON36447
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Age 1-17 years
ITP lasting for more than 12 months
Visting a pediatric hematologist

Exclusion Criteria

Clinical features that are not compatible with the diagnosis of chronic ITP, for example the presence of other autoimmune phenomena, other cytopenias besides thrombocytopenia (e.g. Hb< 6.0 mmol/l, leukocytes < 4.0 x 109/l), features susceptible for hereditary thrombocytopenia
No informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the correlation between platelet function<br /><br>parameters and clinical bleeding tendency in children with chronic ITP. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are 1) quantity and function of regulatory T cells<br /><br>in children with long lasting chronic ITP, 2) response to treatment(s) given in<br /><br>patients with chronic ITP and biological parameters that may be related to this<br /><br>response, 3) HR-QoL in children with chronic ITP and their parents.</p><br>