Investigation of the Effects of Exercise on Gene Expression

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT00916019
• Lead Sponsor: Fukuoka University

Brief Summary

The investigators have previously shown that mild exercise training at the level of lactate threshold (LT) intensity (60 min/day, 5 days/week) improves peripheral insulin sensitivity and insulin-independent glucose disposal of glucose effectiveness, without changes in body weight and body fat (Nishida et al, Diabetes Care, 2001; Nishida et al, Diabetes, 2004). Thus these beneficial effects are likely related to a number of adaptations that occur in skeletal muscle as response to exercise. In the current study, the investigators hypothesised that a single bout of mild exercise performed at LT would be a physiological stimulator of skeletal muscle PGC-1alpha gene, and the repetition of this exercise stimulating PGC-1alpha gene (i.e., training) for 12 weeks would induce coordinated increases in a large number of metabolic genes, as well as other genes potentially important in the prevention of insulin resistance and metabolic syndrome.

Detailed Description

Not available

Study Timeline

• Study Start: 2002-07
• Primary Completion: 2007-12
• Study Completion: 2007-12
• Status Verified: 2009-06
• Study First Submitted: 2009-06-04
• Study First Submitted QC: 2009-06-05
• Study First Posted: 2009-06-08
• Last Update Submitted: 2009-06-15
• Last Update Posted: 2009-06-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 6

Inclusion Criteria

• Men who were all in good health
• All individuals were free from diabetes and none were taking any medications
• All subjects were asked not to change their normal dietary habits, and not to engage in any strenuous physical activity

Exclusion Criteria

• People who undergone regular exercise for at least 2 years
• Smokers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Skeletal muscle PGC-1alpha gene expression and mitochondrial gene expression	3 months

Trial Locations

Locations (1)

Fukuoka University; 🇯🇵 Fukuoka, Japan