Network Interventions to Reduce Disparities in Living Kidney Donation
- Conditions
- End-stage Renal Disease
- Interventions
- Behavioral: Search InterventionBehavioral: Script Intervention
- Registration Number
- NCT05255757
- Lead Sponsor
- Penn State University
- Brief Summary
For this current phase of the larger project, the investigators will survey transplant candidates as well as the participants family and friends to understand the barriers to volunteering and evaluation. This project will examine how network characteristics are associated with eventual living donor kidney transplant outcomes and test the efficacy of evidence-based interventions designed to assist kidney transplant candidates in participant donor search on a multi-center scale.
- Detailed Description
The overall goal is to understand the process and assist participants who do not receive unsolicited offers to be evaluated as a living kidney donor in initiating and effectively conducting these critical conversations with participants kin and friends. In the search intervention, based on what they can tell investigators about the number, type, perceived health, perceived relationship, and potential willingness to donate, as well as analyses of data from the National Health and Nutrition Examination Survey (NHANES) investigators will counsel them on which members of participants family and friendship networks appear most biomedically promising as donors among the subset of these individuals that participants have not ruled out for known medical or perceived relationship reasons. In the rhetorical intervention, investigators will test non-coercive, promising verbal scripts that have proven promising in preliminary tests in vignette experiments in online and phone surveys.
AIM 1: Survey transplant candidates about their social network and transplant-related attitudes, knowledge, and characteristics; and randomize participants into one of two interventions or a control group.
AIM 2: Send network member participants a survey that measures potential donor attributes that are hypothesized to influence donation decisions, such as medical contraindications, blood type, health insurance status, and barriers to living donation.
AIM 3: Test whether participant social networks and interventions affect donation outcomes using medical records and follow-ups provided by Penn and UAB. Investigators will create the first predictive model of potential donor evaluation and actual donation. This information is critical to improve clinical practice and efforts to ethically influence the living donor search process.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 164
- Are KT candidates at the University of Pennsylvania or University of Alabama-Birmingham OR were identified by KT candidate from the University of Pennsylvania or University of Alabama-Birmingham as a network member
- Are adults aged 18 or older
- Are able and willing to consent to participation in the survey
- Person is not a KT candidate at University of Pennsylvania or University of Alabama-Birmingham OR was NOT identified by KT candidate from University of Pennsylvania or University of Alabama-Birmingham as a network member
- Individuals who are not yet 18
- Participant does not speak English
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Search Intervention Search Intervention This group will complete the candidate survey, refer members of their family and social network for participation in a web survey, and be given information about the statistical likelihood that each member of their social network will be free of contraindications for living kidney donation. Both Search and Script Intervention Search Intervention This group will complete the candidate survey, refer members of their family and social network for participation in a web survey, be given information about the statistical likelihood that each member of their social network will be free of contraindications for living kidney donation, and review a set of suggested talking points and an example script to guide discussion of potential living donation with members of their network. Script Intervention Script Intervention This group will complete the survey, refer members of their family and social network for participation in a web survey, and review a set of suggested talking points and an example script to guide discussion of potential living donation with members of their network. Both Search and Script Intervention Script Intervention This group will complete the candidate survey, refer members of their family and social network for participation in a web survey, be given information about the statistical likelihood that each member of their social network will be free of contraindications for living kidney donation, and review a set of suggested talking points and an example script to guide discussion of potential living donation with members of their network.
- Primary Outcome Measures
Name Time Method Death up to 3 years Patient died during the follow-up period
Approvals for living kidney donor candidacy up to 3 years Number of completed living kidney donor evaluations that resulted in approved living kidney donor candidacy for patient
Completed living kidney donor screening questionnaires up to 3 years Number of completed living kidney donation screening questionnaires completed for patient
Completed living kidney donor evaluations up to 3 years Number of living kidney donor evaluations completed for patient
Received a living donor kidney transplant up to 3 years Living donor kidney transplant received by patient
Received a deceased donor kidney transplant up to 3 years Deceased donor kidney transplant received by patient
Preliminary approval from living kidney donor screening questionnaires up to 3 years Number of completed living kidney donor screening that received preliminary approval for patient
- Secondary Outcome Measures
Name Time Method Trust in medical institutions Immediate Respondent is asked to rate their trust in medical institutions.
Concerns about living kidney donation Immediate A set of survey questions asked both before and after the intervention, to assess intermediate attitude outcomes regarding concerns for living kidney donation
Self-rated kidney transplant knowledge Immediate Respondent is asked to rate their level of knowledge related to kidney transplantation.
Preference for living kidney donor Immediate A set of survey questions asked both before and after the intervention, to assess intermediate attitude outcomes regarding preference for living kidney donor
Living donor kidney transplant willingness Immediate A set of survey questions asked both before and after the intervention, to assess intermediate attitude outcomes regarding living donor kidney transplant willingness
Religious views' effect on kidney transplant willingness Immediate Respondent is asked how strongly they agree that their religious views affect their willingness to pursue a kidney transplant.
Trial Locations
- Locations (2)
University of Alabama-Birmingham
🇺🇸Birmingham, Alabama, United States
Penn Medicine-- University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States