Inflammation and Cardiovascular Health in Women
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- HIV/AIDS
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 62
- Locations
- 1
- Primary Endpoint
- Coronary flow reserve on Cardiac PET
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Systemic immune activation and inflammation are believed to play a significant role in the development and clinical course of myocardial infarction (MI). Among women with HIV (WHIV), heightened systemic immune activation and inflammation persist, even when HIV infection is well-treated with contemporary antiretroviral therapeutic regimens. Moreover, WHIV in high-resource regions face a three-fold increased risk of myocardial infarction as compared with matched non-HIV-infected women. The goals of this study are to better understand ways in which HIV infection-incited systemic immune activation and inflammation augment MI risk among women.
Detailed Description
The goals of this study are to better understand ways in which HIV infection-incited systemic immune activation and inflammation augment MI risk among women. To this end, WHIV and non-HIV-infected women will undergo structural and functional cardiovascular imaging studies (Cardiac PET, 99mTc-tilmanocept SPECT/CT, Contrast Enhanced Coronary and Aortic Computed Tomography Angiography) as well as vascular, metabolic/hormonal, and immune phenotyping. Measures of immune activation, arterial inflammation, and cardiovascular pathology will be compared between groups and interrelationships between these parameters will be assessed among WHIV.
Investigators
Markella V. Zanni,M.D.
Associate Professor of Medicine, Harvard Medical School
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Coronary flow reserve on Cardiac PET
Time Frame: Baseline
Secondary Outcomes
- Fractional Flow Reserve(Baseline)
- Hormonal/metabolic parameters(Baseline)
- Markers of inflammation/immune activation(Baseline)
- Markers of mitochondrial disease/dysfunction(Baseline)
- Markers of myocardial stretch/injury(Baseline)
- Arterial inflammation on 99mTc-tilmanocept SPECT/CT(Baseline)
- Atherosclerotic plaque on Contrast Enhanced Coronary and Aortic Computed Tomography Angiography(Baseline)
- Markers of endothelial dysfunction(Baseline)