Inflammation and Cardiovascular Health in Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Coronary flow reserve on Cardiac PET
研究概览
简要总结
Systemic immune activation and inflammation are believed to play a significant role in the development and clinical course of myocardial infarction (MI). Among women with HIV (WHIV), heightened systemic immune activation and inflammation persist, even when HIV infection is well-treated with contemporary antiretroviral therapeutic regimens. Moreover, WHIV in high-resource regions face a three-fold increased risk of myocardial infarction as compared with matched non-HIV-infected women. The goals of this study are to better understand ways in which HIV infection-incited systemic immune activation and inflammation augment MI risk among women.
详细描述
The goals of this study are to better understand ways in which HIV infection-incited systemic immune activation and inflammation augment MI risk among women. To this end, WHIV and non-HIV-infected women will undergo structural and functional cardiovascular imaging studies (Cardiac PET, 99mTc-tilmanocept SPECT/CT, Contrast Enhanced Coronary and Aortic Computed Tomography Angiography) as well as vascular, metabolic/hormonal, and immune phenotyping. Measures of immune activation, arterial inflammation, and cardiovascular pathology will be compared between groups and interrelationships between these parameters will be assessed among WHIV.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 79 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Coronary flow reserve on Cardiac PET
时间窗: Baseline
次要结局
- Fractional Flow Reserve(Baseline)
- Hormonal/metabolic parameters(Baseline)
- Markers of inflammation/immune activation(Baseline)
- Markers of mitochondrial disease/dysfunction(Baseline)
- Markers of myocardial stretch/injury(Baseline)
- Arterial inflammation on 99mTc-tilmanocept SPECT/CT(Baseline)
- Atherosclerotic plaque on Contrast Enhanced Coronary and Aortic Computed Tomography Angiography(Baseline)
- Markers of endothelial dysfunction(Baseline)
研究者
Markella V. Zanni,M.D.
Associate Professor of Medicine, Harvard Medical School
Massachusetts General Hospital