To evaluate the effect of dexmedetomidine added to 0.5% ropivacaine for supraclavicular brachial plexus block on the onset time, duration of sensory, motor block and analgesia.
试验速览
- 阶段
- 4 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- To evaluate the effect of dexmedetomidine added to 0.5% ropivacaine for supraclavicular brachial plexus block on the onset time, duration of sensory, motor block and analgesia.
研究概览
简要总结
**Background and aims:**The effect of perineural dexmedetomidine on the time to onset, quality and duration of motor block with ropivacaine has been equivocal and its interaction with general anaesthesia (GA) has not been reported. We assessed the influence of dexmedetomidine added to 0.5% ropivacaine on the characteristics of supraclavicular brachial plexus block and its interaction with GA.
**Methods:**In a randomised, double blind study, 36 patients scheduled for orthopaedic surgery on the upper limb under supraclavicular block and GA were divided into either R group (35 ml of 0.5% ropivacaine with 0.5 ml of normal saline [n - 18]) or RD group (35 mL of 0.5% ropivacaine with 50 μg dexmedetomidine [n - 18]). The onset time and duration of motor and sensory blockade were noted. The requirement of general anaesthetics was recorded.
**Results:**Both the groups were comparable in demographic characteristics. The time of onset of sensory block was not significantly different. The proportion of patients who achieved complete motor blockade was more in the RD group. The onset of motor block was earlier in group RD than group R (P < 0.05). The durations of analgesia, sensory and motor blockade were significantly prolonged in group RD (P < 0.00). The requirement of entropy guided anaesthetic agents was not different in both groups.
**Conclusions:**The addition of dexmedetomidine to 0.5% ropivacaine improved the time of onset, quality and duration of supraclavicular brachial plexus block but did not decrease the requirement of anaesthetic agents during GA.
**Keywords:**Dexmedetomidine; brachial plexus block; requirement of general anaesthetics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Inclusion criteria: •Patients undergoing upperlimb orthopedic surgery under supraclavicular brachial plexus block and general anaesthesia.
- •â€¢Age more than 18 years.
- •â€¢ASA physical status 1&2.
排除标准
- •Exclusion criteria: •Patients receiving adrenoreceptor agonist or antagonist therapy; •those with a history of cardiac, respiratory, hepatic,or renal failure; •patients with head injury and known psychiatric disordes • and pregnant women were excluded.
结局指标
主要结局
To evaluate the effect of dexmedetomidine added to 0.5% ropivacaine for supraclavicular brachial plexus block on the onset time, duration of sensory, motor block and analgesia.
时间窗: 24 hrs
次要结局
- The secondary objective is to evaluate whether dexmedetomidine added to 0.5% ropivacaine for supraclavicular brachial plexus block reduces the requirements of general anaesthetics.(24 hrs)