Can restricting the blood supply to part of the stomach lead to weight loss in severely overweight patients?

Phase 2

• Conditions: Obesity; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN16158402
• Lead Sponsor: Imperial College London

Brief Summary

2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37770263/ (added 29/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-09-27
• Last Update Posted: 9 October 2023
• Study Completion: 2024-07-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

1. Adults aged 18-70 years
2. BMI 35-50 kg/m²
3. Ability to lie supine
4. Appropriate anatomy of the left gastric artery and coeliac plexus on CT angiogram
5. Willing and able to provide informed consent

Exclusion Criteria

1. Haematological, hepatic or renal dysfunction
2. Weight >150 kg
3. HbA1c >8.5%
4. Known renal, vascular or aortic disease
5. Malignancy
6. Prior major abdominal surgery, prior gastric or bariatric surgery
7. Prior abdominal radiotherapy
8. Gastrointestinal (GI) bleeding or bleeding diathesis
9. Allergy to iodinated contrast,
10. Known gastric ulceration or active H. pylori infection
11. Positive pregnancy test in females of childbearing age
12. Chronic Non-steroidal anti-inflammatory drug (NSAID) use
13. Current use of insulin or sulphonylurea
14. Current use of anti-tricyclic anti-depressants or steroids

Study & Design

• Study Type: Interventional
• Study Design: Not specified