Endogenous steroid suppression in children and adolescents with nephrotic syndrome treated with steroids

Not yet recruiting

• Conditions: Drug-induced adrenocortical insufficiency,

• Registration Number: CTRI/2021/06/034046
• Lead Sponsor: Maulana Azad Medical College and associated Lok Nayak Hospital

Brief Summary

To find out proportion of patients with nephrotic syndrome who are treated with steroids having endogenous steroid Suppression, using low dose ACTH.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-04-06
• Study Start: 2021-06-14

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Children and adolescents with steroid sensitive or steroid resistant nephrotic syndrome in the age group of 1-18 years, presently in remission (partial or complete) and 1.
• Who received daily prednisolone in any dosage for ≥ 2 weeks in the last 1 year and they are now off steroids or 2.
• Are presently receiving low dose alternate day prednisolone therapy (<1 mg/kg/day) for atleast 8 weeks.

Exclusion Criteria

• 1.Children with nephrotic syndrome who received daily corticosteroid therapy in any dosages in the last 8 weeks.
• 2.Children with nephrotic syndrome having serious bacterial infections like pneumonia, cellulitis, sepsis, meningitis etc or are hospitalised for any reason.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of patients having adrenocortical insufficiency defined as serum cortisol 18 ug/dL by a low dose ACTH stimulation test.	From OPD visit to individual patient samples will be analysed within five days. | Thesis will be done in a year for the suggested sample size.

Secondary Outcome Measures

Name	Time	Method
Disease type, duration, cumulative steroid doses, correlation of steroid doses to baseline and stimulated serum cortisol values.

Trial Locations

Locations (1)

Department of paediatrics,Lok Nayak Hospital.; 🇮🇳 Delhi, DELHI, India

Department of paediatrics,Lok Nayak Hospital.

🇮🇳Delhi, DELHI, India

Ganeshkrishna M

Principal investigator

8012435703

ganeshmkrishna@gmail.com