Factors of Steroid Dependency in Idiopathic Nephrotic Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 351
- 试验地点
- 1
- 主要终点
- define pharmacogenetic factors of steroid dependency
研究概览
简要总结
The primary purpose of the study is to identify the factors of steroid dependency in childhood idiopathic nephrotic syndrome. The steroid dependency is defined by a relapse of nephrotic syndrome within the 3 weeks that follow the withdrawal of steroid therapy after the first manifestation. Different clinical and biological factors will be analyzed: age of first manifestation, delay of remission, ethnicity, and preceding viral infection, geolocalization in the Parisian area, genoprevalence of herpes viruses and polymorphisms in the genes involved in the response to steroid therapy.
详细描述
Patients with a steroid dependent nephrotic syndrome will be compared to those with a non steroid dependent form of nephrotic syndrome at the end of the first manifestation. An additional blood volume will be sampled in patients and controls during a scheduled biological check-up for the initial disease. Genetics factors will be checked using a DNA chips devoted to the response to steroid therapy and viral genome of EBV, CMV, HHV7 will be searched for using PCR reaction in total blood DNA extract.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 年龄范围
- 6 Months 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children below 16 years
- •first manifestation of nephrotic syndrome
- •steroid sensitivity according to the recommendations of the french "pediatric society nephrology"
排除标准
- •patients who don't stay in Paris during the study
结局指标
主要结局
define pharmacogenetic factors of steroid dependency
时间窗: 28.5 months
次要结局
- Dynamic of the epidemiology of idiopathic nephrotic syndrome in the Paris Area(28.5 months)
- parameters of the immune response against herpesvirus, specially the cellular production of interferon induced by specific viral peptides(28.5 months)
- Analysis of cortico-dependence factors(Day 1)
- Analysis of susceptibility factors that generate the appearance of the Idiopathic Nephrotic Syndrome(Day 1)