Pregnancies following the use of sequential treatment of metformin and incremental doses of letrozole in clomiphen-resistant women with polycystic ovary syndrome
Not Applicable
- Conditions
- Poly cystic ovarian syndrome.Polycystic ovarian syndrome
- Registration Number
- IRCT201109073386N3
- Lead Sponsor
- Semnan university of medical scienses
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 106
Inclusion Criteria
women who were 19-42 years of age with period of infertility more than 1.5 years; normal serum prolactin and thyroid function tests; having documented patent tubes by hysterosalpingography; no other infertility factor and failed to ovulate with a dose of CC of 150 mg/day for 5 days from day 3 of the period.The women were excluded from the study if they were diabetic; taking any medication that could influence carbohydrate metabolism; had hypertension or abnormal renal or liver function tests; and undergone ovarian drilling.Hirsutism was diagnosed when the Ferriman and Gallway score is >8
The diagnosis of PCOS was according to the Rotterdam Criteria.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ovulation, Pregnancy and Cumulative pregnancy rates in different doses of letrozole. Timepoint: During and the end of treatment. Method of measurement: Sonography and BHCG.
- Secondary Outcome Measures
Name Time Method The mean number of follicles= 18 mm, the mean of follicular size and endometrial thickness on the day of HCG administration. Timepoint: During treatment. Method of measurement: Sonograhy and BHCG.