Saliva as Early Detection Tool for Oral Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- salivary cytology
研究概览
简要总结
Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing.
Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.
详细描述
The project aims to evaluate salivary cytology, genes and biochemistry of the healthy normal population and compare it with that of the oral submucous fibrosis and oral cancer. For salivary experiments 3 cc of fresh saliva will be collected and analysed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
- •patients with oral submucous fibrosis
- •patients with biopsy proven oral cancer
排除标准
- •patients with oral infection
结局指标
主要结局
salivary cytology
时间窗: 1 year
A method will be developed for evaluation of detection of oral cancer
evaluation of biochemicals of saliva
时间窗: 1 year
saliva of three groups will be compared on the basis of salivary enzymes
evaluation of telomere length of salivary cells
时间窗: 1 year
Telomere length will be evaluation in the saliva of three groups
次要结局
未报告次要终点
研究者
Prof. Binafsha Manzoor Syed
Professor
Liaquat University of Medical & Health Sciences