Effect of microneedling with vitamin c serum application for treatment of melasma
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Improvment in Melasma Area Severity Index score
研究概览
简要总结
This study is Randomized controlled trial of effect of microneedling with vitamin c serum application for treatment of melasma.
Vitamin C inhibits melanogenesis, promotes collagen biosynthesis, prevents free radical formation and accelerates wound healing. It is best used after techniques that enhances transdermal delivery of agents such as microneedling. Microneedling is a very simple, safe, effective, and minimally invasive therapeutic technique which involves superficial and controlled puncturing of skin by rolling with miniature fine needles. It is widely used as a transdermal delivery system for therapeutic drugs and vaccine
The study will be conducted for a period of 4 months at Dr D.Y Patil medical college, Pune. The primary outcome will be improvement in MASI score and secondary will be improvement in quality of life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients of mixed and epidermal melasma reporting to OPD.
- •Patient willing to participate and have signed the informed consent 3)Patients who are on no concurrent systemic or topical treatment for melasma.
排除标准
- •Patients with dermal melasma 2)Patients with fever or signs of any systemic or local inflammation or infection.
- •Inability to come for regular follow-ups.
- •Patients not willing to participate in the study 5)Moderate to severe chronic skin disease such as eczema and psoriasis 6)Blood dyscrasias, patients on anticoagulant therapy 7)Extreme keloidal tendency 8)Patient on chemo/radiotherapy.
结局指标
主要结局
Improvment in Melasma Area Severity Index score
时间窗: 3 months
次要结局
- Any effect on quality of life(3 Months)