Study of effect of dermaroller with vitamin c serum application for treatment of darkened facsial skin

Phase 3

Not yet recruiting

• Conditions: Chloasma, (2) ICD-10 Condition: L814||Other melanin hyperpigmentation,

• Registration Number: CTRI/2019/05/019327
• Lead Sponsor: Alisha Mittal

Brief Summary

This study is Randomized controlled trial of effect of microneedling with vitamin c serum application for treatment of melasma.

Vitamin C inhibits melanogenesis, promotes collagen biosynthesis, prevents free radical formation and accelerates wound healing. It is best used after techniques that enhances transdermal delivery of agents such as microneedling. Microneedling is  a very simple, safe, effective, and minimally invasive therapeutic technique which involves superficial and controlled puncturing of skin by rolling with miniature fine needles. It is widely used as a transdermal delivery system for therapeutic drugs and vaccine 

The study will be conducted for a period of 4 months at Dr D.Y Patil medical college, Pune. The primary outcome will be improvement in MASI score and secondary will be improvement in quality of life.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-06
• Last Update Posted: 2019-05-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

• 1. All patients of mixed and epidermal melasma reporting to OPD.
• 2. Patient willing to participate and have signed the informed consent 3)Patients who are on no concurrent systemic or topical treatment for melasma.

Exclusion Criteria

• 1)Patients with dermal melasma 2)Patients with fever or signs of any systemic or local inflammation or infection.
• 3)Inability to come for regular follow-ups.
• 4)Patients not willing to participate in the study 5)Moderate to severe chronic skin disease such as eczema and psoriasis 6)Blood dyscrasias, patients on anticoagulant therapy 7)Extreme keloidal tendency 8)Patient on chemo/radiotherapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvment in Melasma Area Severity Index score	3 months

Secondary Outcome Measures

Name	Time	Method
Any effect on quality of life	3 Months

Trial Locations

Locations (1)

Dr D.Y Patil Medical college; 🇮🇳 Pune, MAHARASHTRA, India

Dr D.Y Patil Medical college

🇮🇳Pune, MAHARASHTRA, India

Alisha Mittal

Principal investigator

7042096656

alisha091@gmail.com