Optimizing Parameters for Long-pulsed Nd:YAG Laser for Reducing Hair Shaft Diameter

Not Applicable

Completed

• Conditions: Androgenetic Alopecia; Hair Loss/Baldness
• Interventions: Device: Long-pulsed, 1064nm Nd-YAG laser

• Registration Number: NCT03394235
• Lead Sponsor: Institute of Dermatology, Thailand

Brief Summary

This study evaluates the optimizing parameters of long pulse Nd:YAG Laser for reducing the size of hair shaft diameter of the donor for hair transplantation. All participants will receive long-pulsed Nd-YAG laser treatments with three different parameters at the occipital area.

Detailed Description

Since the beginning of hair transplantation era, hair transplant technique has been greatly improved to achieve the best natural looking of hairline and hair density. Most Asians tend to have large size of hair shaft at the donor area, which often cause unnatural look of the hairline at the frontal area after hair transplantation due to the contrast between the transplanted hair and the original hair.

The idea of reducing the size of the hair shaft in the certain part of donor area before being transplanted to the frontal hairline becomes appealing. This transection is being practiced extensively in the field of cosmetic medicine by using long-pulsed Neodymium-Doped:Yttrium Aluminum Gamet (Nd:YAG), a laser treatment for permanent hair removal and vascular lesions.

Study Timeline

• Study First Submitted: 2018-01-02
• Study First Submitted QC: 2018-01-06
• Study First Posted: 2018-01-09
• Study Start: 2018-02-02
• Primary Completion: 2018-11-14
• Status Verified: 2019-01
• Study Completion: 2019-01-16
• Last Update Submitted: 2019-01-29
• Last Update Posted: 2019-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Men and women, aged 25-60 years with AGA or healthy
• Completed informed consent form

Exclusion Criteria

• Pregnancy or breastfeeding
• Acute infection on the scalp or any systemic infection
• Immunocompromised host
• Chronic wasting diseases
• Use of any medications which may affect hair loss such as anticoagulants, anti-hypertensive, hormones, anticonvulsants, retinoid, mood stabilizers and antidepressants
• Unstable medical problems which may affect hair loss such as thyroid diseases, autoimmune diseases, myocardial infarction, coronary bypass surgery, unstable angina, cardiac arrhythmias, congestive heart failure, cerebrovascular accident and psychiatric problems
• Hair thinning at the occipital area

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Long-pulsed, 1064nm Nd-YAG laser	Long-pulsed, 1064nm Nd-YAG laser	All participants will receive long-pulsed, 1064nm Nd-YAG laser treatments with three different parameters at the occipital area.

Primary Outcome Measures

Name	Time	Method
Evaluate the changes in hair density at the treated sites.	24 weeks	Evaluate changes in hair density at the treated sites following long-pulsed, 1064 Nd-YAG laser sessions every 8 weeks or until the treatment endpoint is reached before or at 24 weeks.

Secondary Outcome Measures

Name	Time	Method
Evaluate the changes in hair diameter at the treated sites.	24 weeks	Evaluate the changes in hair diameter at the treated sites following long-pulsed, 1064 Nd-YAG laser sessions every 8 weeks or until the treatment endpoint is reached before or at 24 weeks.

Trial Locations

Locations (1)

Institute of Dermatology; 🇹🇭 Bangkok, Thailand