The effect of high-dose vitamin C in patients with sepsis: A systematic review and meta-analysis of randomized controlled trials
Not Applicable
- Conditions
- Sepsis
- Registration Number
- JPRN-UMIN000040528
- Lead Sponsor
- Cleveland Clinic.
- Brief Summary
Eleven randomized controlled trials (n = 1,737 patients) were included in this meta-analysis. High-dose IV vitamin C was not associated with a significantly lower short-term mortality (RR, 0.88; 95% CI, 0.73-1.06; p = 0.18; I2 = 29%) but was associated with a significantly shorter duration of vasopressor use (SMD, -0.35; 95% CI, -0.63 to -0.07; p < 0.01; I2 = 80%) and a significantly greater decline in the SOFA score at 72-96 hours (SMD, -0.20; 95% CI, -0.32 to -0.08; p < 0.01; I2 = 16%).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 1737
Inclusion Criteria
Not provided
Exclusion Criteria
We excluded articles that included patients <18 years, published in non-English and are conference proceedings.
Study & Design
- Study Type
- Others,meta-analysis etc
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method