Environmental & Genetic Influences on Vitamin D Status
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- 25(OH)D levels
研究概览
简要总结
The purpose of this study is to determine the effect of environmental and genetic influences on Vitamin D status.
详细描述
Vitamin D deficiency is a common problem. The principal source of vitamin D for humans is solar exposure, with cutaneous synthesis of vitamin D by photoconversion of 7-dehydrocholesterol in the skin to pre-vitamin D3. Latitude, altitude, season, skin pigmentation, and age are recognized factors that influence how much vitamin D can be made by solar exposure. Surprisingly, Vitamin D deficiency has been described in people dwelling in southern Florida and in surfers in Hawaii. We hypothesize that genetic variations in vitamin metabolism accounts for these differences.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to consent and come for a study visit.
- •Male or female between ages 18-
- •Sun exposure >3 hours daily for at least 5 days weekly for the last 3 months.
排除标准
- •Unable to consent or come to a visit
- •Taking Vitamin D supplements, anticonvulsants, barbiturates, steroids, having granulomatous disease, or liver or kidney disease as these medications and conditions interfere with Vitamin D metabolism.
- •Related to another participant by blood.
结局指标
主要结局
25(OH)D levels
时间窗: 1 month
25(OH)D levels were measured at the only visit
次要结局
- Genetic testing of 13 candidate genes(1 month)