Acute Kidney Injury in Adult Patients Supported by VA-ECMO

Completed

• Conditions: Cardiogenic Shock; Acute Kidney Injury
• Interventions: Other: No intervention

• Registration Number: NCT04082312
• Lead Sponsor: Groupe Hospitalier Pitie-Salpetriere

Brief Summary

Post-cardiotomy cardiogenic shock (PCCS) occurs in 2-6% of patients undergoing cardiac surgery, and 1% of cardiac surgery patients will require mechanical circulatory support using Veno-Arterial ExtraCorporeal Membrane Oxygenation (VA-ECMO). Acute Kidney Injury is a frequent complication in this population and negatively impacts the survival. We aimed to determine whether the timing of ECMO implantation influence the renal prognosis of these patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-05-01
• Primary Completion: 2019-05-05
• Study Completion: 2019-07-05
• Study First Submitted: 2019-09-05
• Study First Submitted QC: 2019-09-05
• Study First Posted: 2019-09-09
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-11
• Last Update Posted: 2023-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 347

Inclusion Criteria

• All patients admitted in post-operative of cardiac surgery
• Assisted by VA-ECMO

Exclusion Criteria

• Chronic hemodialysis
• Death occurring within the first 48 hours of VA-ECMO implantation
• Multiple VA-ECMO during the same hospitalization.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 3	No intervention	Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + died before D10 without KDIGO stage 3 AKI
Group 1	No intervention	Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + with KDIGO stage 3 AKI
Group 2	No intervention	Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + without KDIGO stage 3 AKI and alive at D10

Primary Outcome Measures

Name	Time	Method
Occurrence of a stage 3 AKI	Day 10 after ECMO implantation	Number of Participants with Stage 3 Acute Kidney Injury according to the Kidney Disease: Improving Global Outcomes (KDIGO) group

Secondary Outcome Measures

Name	Time	Method
Mortality at Day 30	Day 30 after ECMO implantation	Number of Deceased Participants
Mortality at 6 months	6 months after ECMO implantation	Number of Deceased Participants

Trial Locations

Locations (1)

Dr Adrien Bouglé; 🇫🇷 Paris, France