Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission

Phase 3

Completed

Conditions: Myelodysplastic Syndrome With Excess Blasts
Adult Acute Myeloid Leukemia in Remission
Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With Minimal Differentiation
Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A
Adult Erythroleukemia
Adult Pure Erythroid Leukemia
Alkylating Agent-Related Acute Myeloid Leukemia
Recurrent Adult Acute Myeloid Leukemia
Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1

Interventions: Drug: Tipifarnib
Procedure: Clinical Observation

Registration Number: NCT00093470

Lead Sponsor: National Cancer Institute (NCI)

Brief Summary: This randomized phase III trial studies tipifarnib in treating patients with acute myeloid leukemia (AML) in remission. Tipifarnib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. It is not yet known whether tipifarnib is more effective than observation alone in preventing the recurrence of AML.

Detailed Description: PRIMARY OBJECTIVES:

I. To compare R115777 (tipifarnib) maintenance therapy to observation only with respect to disease-free survival (DFS) in patients with AML in second or subsequent complete remission or in complete response (CR) following primary induction failure.

SECONDARY OBJECTIVES:

I. To compare overall survival of patients in both arms. II. To evaluate the long-term safety and toxicity of extended administration of R115777 in AML patients in remission.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive tipifarnib orally (PO) twice daily (BID) on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients undergo observation only.

After completion of study treatment, patients are followed up for 5 years.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 144

Inclusion Criteria

Patients eligible to enter this study must fall into one of these categories:
- Patients in first remission following primary induction failure
- Patients must have received at least two chemotherapy induction regimens
- Patients in second or subsequent remission
- Patients > 60 years old in first remission
Patients must be in complete remission (CR) or morphologic remission (MR) by blood counts and bone marrow studies to enter the study
- Confirmatory bone marrow must be performed =< 2 weeks prior to randomization
Patients must have morphologic proof (from bone marrow aspirate, smears or touch preps of marrow biopsy) that they had AML of one of the following types prior to achievement of CR/MR
- Acute myeloblastic leukemia, minimal differentiation (French-American-British [FAB] M0)
- Acute myeloblastic leukemia without differentiation (FAB M1)
- Acute myeloblastic leukemia with maturation (FAB M2)
- Acute myelomonocytic leukemia (FAB M4)
- Acute monocytic leukemia (FAB M5)
- Acute erythroleukemia (FAB M6)
- Acute megakaryocytic leukemia (FAB M7)
- Refractory anemia with excess blasts in transformation (RAEB-T)
- AML by World Health Organization (WHO) criteria
- Acute myeloid leukemia with multilineage dysplasia
Patients with acute promyelocytic leukemia (FAB M3) are not eligible
Patients must be registered within 60 days of completion of therapy for the current remission; patients are eligible if they meet any of the criteria below:
- Within 60 days of remission (CR or MR) by peripheral blood counts following induction therapy or
- Within 60 days of discharge from the hospital following induction therapy or
- Within 60 days of discharge from the hospital following post-remission therapy or
- Within 60 days of recovery of blood counts following last dose of chemotherapy
All of the patients below are eligible for study entry:
- Patients who have received consolidation therapy
- Patients who have not received any consolidation or post remission therapy
- Patients who have had an autologous stem cell transplant
Patients who have received an allogeneic transplant (bone marrow transplant [BMT] or peripheral stem cell transplant [PSCT]) in their current remission are ineligible; patients who have had an allogeneic transplant in a previous remission and are currently in remission after subsequent relapse are eligible
Patients with a history of extramedullary disease are eligible if they are in complete remission at the time of study entry and no longer requiring therapy for their extramedullary disease
Patients must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study < 2 weeks prior to randomization to rule out pregnancy
Women of childbearing potential and sexually active males are strongly advised to use an accepted and effective method of contraception
Patients must not be known to have an allergy to imidazole drugs, such as clotrimazole ketoconazole, miconazole, econazole, or terconazole; this does not include fluconazole, voriconazole, or itraconazole
Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 2
Patients must not have active cardiac or pulmonary disease; but patient will be eligible if disease is medically controlled
Patients must not have active renal disease; creatinine must be =< 1.5 x upper limit of normal
Patients must not have active hepatic disease; total or direct bilirubin must be < 2 mg/dl
Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) and serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) must be =< 2.5 times the upper limit of normal
Absolute neutrophil count (ANC) >= 1000/mm^3
Platelet count >= 50,000/mm^3
Patients must not be taking a hepatic enzyme-inducing anti-convulsant; a patient will not be eligible for the study if the patient is currently taking one of these agents and cannot be switched to a non-hepatic enzyme-inducing anti-convulsant

Exclusion Criteria

Not provided

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Arm A (tipifarnib)	Tipifarnib	Patients receive tipifarnib PO BID on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Arm B (clinical observation)	Clinical Observation	Patients undergo observation only.

Primary Outcome Measures

Name	Time	Method
Disease-free Survival	Assessed monthly for the first 6 months then every 3 months or as clinically indicated, up to 5 years.	Disease-free survival (DFS) is defined as the time from randomization to relapse or death without relapse.

Secondary Outcome Measures

Name	Time	Method
Overall Survival	Assessed monthly for the first 6 months then every 3 months or as clinically indicated, up to 5 years.	Overall survival (OS) is defined as the time from randomization to death from any cause.

Trial Locations

Locations (340): Mason District Hospital
🇺🇸
Havana, Illinois, United States
Pennsylvania Hospital
🇺🇸
Philadelphia, Pennsylvania, United States
Graham Hospital Association
🇺🇸
Canton, Illinois, United States
West Michigan Cancer Center
🇺🇸
Kalamazoo, Michigan, United States
Kalamazoo Center for Medical Studies
🇺🇸
Kalamazoo, Michigan, United States
Central Washington Hospital
🇺🇸
Wenatchee, Washington, United States
Memorial Hospital
🇺🇸
Carthage, Illinois, United States
Fort Wayne Medical Oncology and Hematology Inc-Parkview
🇺🇸
Fort Wayne, Indiana, United States
Decatur Memorial Hospital
🇺🇸
Decatur, Illinois, United States
Loyola University Medical Center
🇺🇸
Maywood, Illinois, United States
Louisiana State University Health Sciences Center Shreveport
🇺🇸
Shreveport, Louisiana, United States
Mount Nittany Medical Center
🇺🇸
State College, Pennsylvania, United States
WellSpan Health-York Hospital
🇺🇸
York, Pennsylvania, United States
Broward Health Medical Center
🇺🇸
Fort Lauderdale, Florida, United States
William Beaumont Hospital-Royal Oak
🇺🇸
Royal Oak, Michigan, United States
Aultman Health Foundation
🇺🇸
Canton, Ohio, United States
Marshfield Clinic-Wausau Center
🇺🇸
Wausau, Wisconsin, United States
Diagnostic and Treatment Center
🇺🇸
Weston, Wisconsin, United States
Western Illinois Cancer Treatment Center
🇺🇸
Galesburg, Illinois, United States
Park Nicollet Clinic - Saint Louis Park
🇺🇸
Saint Louis Park, Minnesota, United States
Northwestern University
🇺🇸
Chicago, Illinois, United States
Jesse Brown Veterans Affairs Medical Center
🇺🇸
Chicago, Illinois, United States
Rush University Medical Center
🇺🇸
Chicago, Illinois, United States
University of Chicago Comprehensive Cancer Center
🇺🇸
Chicago, Illinois, United States
Mercy Hospital and Medical Center
🇺🇸
Chicago, Illinois, United States
Swedish Covenant Hospital
🇺🇸
Chicago, Illinois, United States
Case Western Reserve University
🇺🇸
Cleveland, Ohio, United States
MetroHealth Medical Center
🇺🇸
Cleveland, Ohio, United States
Cleveland Clinic Foundation
🇺🇸
Cleveland, Ohio, United States
Boston Medical Center
🇺🇸
Boston, Massachusetts, United States
Fred Hutchinson Cancer Research Center
🇺🇸
Seattle, Washington, United States
Kaiser Permanente Washington
🇺🇸
Seattle, Washington, United States
Swedish Medical Center-First Hill
🇺🇸
Seattle, Washington, United States
University of Washington Medical Center
🇺🇸
Seattle, Washington, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
🇺🇸
Miami, Florida, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
🇺🇸
Houston, Texas, United States
Baylor Saint Luke's Medical Center
🇺🇸
Houston, Texas, United States
Ben Taub General Hospital
🇺🇸
Houston, Texas, United States
Michael E DeBakey VA Medical Center
🇺🇸
Houston, Texas, United States
University Medical Center of Southern Nevada
🇺🇸
Las Vegas, Nevada, United States
Kaiser Permanente-San Diego Mission
🇺🇸
San Diego, California, United States
Abbott-Northwestern Hospital
🇺🇸
Minneapolis, Minnesota, United States
The Jewish Hospital
🇺🇸
Cincinnati, Ohio, United States
Welch Cancer Center
🇺🇸
Sheridan, Wyoming, United States
Intermountain Health Care
🇺🇸
Salt Lake City, Utah, United States
Utah Cancer Specialists-Salt Lake City
🇺🇸
Salt Lake City, Utah, United States
Instituto Nacional de Enfermedades Neoplasicas
🇵🇪
Lima, Peru
Billings Clinic Cancer Center
🇺🇸
Billings, Montana, United States
Eastern Montana Cancer Center
🇺🇸
Miles City, Montana, United States
Saint Vincent Healthcare
🇺🇸
Billings, Montana, United States
Saint Vincent Frontier Cancer Center
🇺🇸
Billings, Montana, United States
Deaconess Medical Center
🇺🇸
Billings, Montana, United States
Saint James Community Hospital and Cancer Treatment Center
🇺🇸
Butte, Montana, United States
Benefis Healthcare- Sletten Cancer Institute
🇺🇸
Great Falls, Montana, United States
Saint Patrick Hospital - Community Hospital
🇺🇸
Missoula, Montana, United States
Henry Ford Hospital
🇺🇸
Detroit, Michigan, United States
University of Oklahoma Health Sciences Center
🇺🇸
Oklahoma City, Oklahoma, United States
Holy Cross Hospital
🇺🇸
Fort Lauderdale, Florida, United States
Smilow Cancer Hospital-Torrington Care Center
🇺🇸
Torrington, Connecticut, United States
Jupiter Medical Center
🇺🇸
Jupiter, Florida, United States
Saint Luke's South Hospital
🇺🇸
Overland Park, Kansas, United States
Galesburg Cottage Hospital
🇺🇸
Galesburg, Illinois, United States
Hematology Oncology Associates of Illinois - Skokie
🇺🇸
Skokie, Illinois, United States
Sarah Culbertson Memorial Hospital
🇺🇸
Rushville, Illinois, United States
Midwest Center for Hematology Oncology
🇺🇸
Joliet, Illinois, United States
Franciscan St. James Health-Olympia Fields Campus
🇺🇸
Olympia Fields, Illinois, United States
Hopedale Medical Complex - Hospital
🇺🇸
Hopedale, Illinois, United States
Cancer Center of Kansas - Pratt
🇺🇸
Pratt, Kansas, United States
Boca Raton Regional Hospital
🇺🇸
Boca Raton, Florida, United States
Hematology and Oncology Associates
🇺🇸
Chicago, Illinois, United States
MedStar Georgetown University Hospital
🇺🇸
Washington, District of Columbia, United States
Phoebe Putney Memorial Hospital
🇺🇸
Albany, Georgia, United States
Memorial Hospital of South Bend
🇺🇸
South Bend, Indiana, United States
Mercy Medical Center-Sioux City
🇺🇸
Sioux City, Iowa, United States
Genesis Medical Center - East Campus
🇺🇸
Davenport, Iowa, United States
Memorial Hospital of Arkansas City
🇺🇸
Arkansas City, Kansas, United States
Genesis Medical Center - West Campus
🇺🇸
Davenport, Iowa, United States
Hospital District Sixth of Harper County
🇺🇸
Anthony, Kansas, United States
Midwest Cancer Research Group Incorporated
🇺🇸
Skokie, Illinois, United States
Pekin Hospital
🇺🇸
Pekin, Illinois, United States
NorthShore Hematology Oncology-Libertyville
🇺🇸
Libertyville, Illinois, United States
Elkhart General Hospital
🇺🇸
Elkhart, Indiana, United States
Community Howard Regional Health
🇺🇸
Kokomo, Indiana, United States
Cancer Center of Kansas - Ottawa
🇺🇸
Ottawa, Kansas, United States
Associates In Womens Health
🇺🇸
Wichita, Kansas, United States
Cancer Center of Kansas - Salina
🇺🇸
Salina, Kansas, United States
Cancer Center of Kansas-Independence
🇺🇸
Independence, Kansas, United States
Cancer Center of Kansas - El Dorado
🇺🇸
El Dorado, Kansas, United States
Rush - Copley Medical Center
🇺🇸
Aurora, Illinois, United States
Saint Joseph Medical Center
🇺🇸
Bloomington, Illinois, United States
Saint Mary's Hospital and Regional Medical Center
🇺🇸
Grand Junction, Colorado, United States
University Cancer and Blood Center LLC
🇺🇸
Athens, Georgia, United States
NorthShore University HealthSystem-Evanston Hospital
🇺🇸
Evanston, Illinois, United States
Proctor Hospital
🇺🇸
Peoria, Illinois, United States
OSF Saint Francis Medical Center
🇺🇸
Peoria, Illinois, United States
Deerpath Medical Associates
🇺🇸
Lake Forest, Illinois, United States
Heartland Oncology and Hematology LLP
🇺🇸
Council Bluffs, Iowa, United States
Mcdonough District Hospital
🇺🇸
Macomb, Illinois, United States
Illinois CancerCare-Ottawa Clinic
🇺🇸
Ottawa, Illinois, United States
Southwest Medical Center
🇺🇸
Liberal, Kansas, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
🇺🇸
Savannah, Georgia, United States
Eureka Hospital
🇺🇸
Eureka, Illinois, United States
Beebe Medical Center
🇺🇸
Lewes, Delaware, United States
Illinois Cancer Specialists-Niles
🇺🇸
Niles, Illinois, United States
Methodist Medical Center of Illinois
🇺🇸
Peoria, Illinois, United States
Illinois Valley Hospital
🇺🇸
Peru, Illinois, United States
Memorial Medical Center
🇺🇸
Springfield, Illinois, United States
McFarland Clinic PC-William R Bliss Cancer Center
🇺🇸
Ames, Iowa, United States
Saint Joseph Regional Medical Center-Mishawaka
🇺🇸
Mishawaka, Indiana, United States
Medical Oncology and Hematology Associates-West Des Moines
🇺🇸
Clive, Iowa, United States
Franciscan Saint Francis Health-Beech Grove
🇺🇸
Beech Grove, Indiana, United States
The Community Hospital
🇺🇸
Munster, Indiana, United States
Perry Memorial Hospital
🇺🇸
Princeton, Illinois, United States
Bromenn Regional Medical Center
🇺🇸
Normal, Illinois, United States
Valley Radiation Oncology
🇺🇸
Peru, Illinois, United States
Cancer Center of Kansas - Dodge City
🇺🇸
Dodge City, Kansas, United States
North Colorado Medical Center
🇺🇸
Greeley, Colorado, United States
Saint Anthony Hospital
🇺🇸
Lakewood, Colorado, United States
Cancer Center of Kansas - Wichita
🇺🇸
Wichita, Kansas, United States
Cancer Center of Kansas - Winfield
🇺🇸
Winfield, Kansas, United States
Baton Rouge General Medical Center
🇺🇸
Baton Rouge, Louisiana, United States
Maine General Medical Center-Thayer
🇺🇸
Waterville, Maine, United States
Tufts Medical Center
🇺🇸
Boston, Massachusetts, United States
Wichita NCI Community Oncology Research Program
🇺🇸
Wichita, Kansas, United States
Eastern Maine Medical Center
🇺🇸
Bangor, Maine, United States
Ochsner Health Center-Summa
🇺🇸
Baton Rouge, Louisiana, United States
Overton Brooks Veteran's Administration Medical Center
🇺🇸
Shreveport, Louisiana, United States
Lahey Hospital and Medical Center
🇺🇸
Burlington, Massachusetts, United States
Union Hospital of Cecil County
🇺🇸
Elkton, Maryland, United States
Baystate Medical Center
🇺🇸
Springfield, Massachusetts, United States
Borgess Medical Center
🇺🇸
Kalamazoo, Michigan, United States
Essentia Health Cancer Center
🇺🇸
Duluth, Minnesota, United States
Mercy Hospital
🇺🇸
Scranton, Pennsylvania, United States
Saint Francis Regional Medical Center
🇺🇸
Shakopee, Minnesota, United States
Minnesota Oncology Hematology PA-Woodbury
🇺🇸
Woodbury, Minnesota, United States
Ridgeview Medical Center
🇺🇸
Waconia, Minnesota, United States
Hematology and Oncology Clinic
🇺🇸
Hattiesburg, Mississippi, United States
Centerpoint Medical Center LLC
🇺🇸
Independence, Missouri, United States
Heartland Regional Medical Center
🇺🇸
Saint Joseph, Missouri, United States
Berdeaux, Donald MD (UIA Investigator)
🇺🇸
Great Falls, Montana, United States
Glacier Oncology PLLC
🇺🇸
Kalispell, Montana, United States
Montana Cancer Specialists
🇺🇸
Missoula, Montana, United States
Great Falls Clinic
🇺🇸
Great Falls, Montana, United States
Kalispell Medical Oncology
🇺🇸
Kalispell, Montana, United States
Saint Peter's Community Hospital
🇺🇸
Helena, Montana, United States
Kalispell Regional Medical Center
🇺🇸
Kalispell, Montana, United States
University of Pennsylvania/Abramson Cancer Center
🇺🇸
Philadelphia, Pennsylvania, United States
Rutherford Hospital
🇺🇸
Rutherfordton, North Carolina, United States
Weill Medical College of Cornell University
🇺🇸
New York, New York, United States
Hematology Oncology Associates of Central New York-East Syracuse
🇺🇸
East Syracuse, New York, United States
Stony Brook University Medical Center
🇺🇸
Stony Brook, New York, United States
Fox Chase Cancer Center
🇺🇸
Philadelphia, Pennsylvania, United States
Summa Akron City Hospital/Cooper Cancer Center
🇺🇸
Akron, Ohio, United States
Akron General Medical Center
🇺🇸
Akron, Ohio, United States
Carolinas Medical Center/Levine Cancer Institute
🇺🇸
Charlotte, North Carolina, United States
Geisinger Wyoming Valley/Henry Cancer Center
🇺🇸
Wilkes-Barre, Pennsylvania, United States
Samaritan North Health Center
🇺🇸
Dayton, Ohio, United States
Avera Cancer Institute
🇺🇸
Sioux Falls, South Dakota, United States
Lehigh Valley Hospital-Cedar Crest
🇺🇸
Allentown, Pennsylvania, United States
AnMed Health Hospital
🇺🇸
Anderson, South Carolina, United States
Spartanburg Medical Center
🇺🇸
Spartanburg, South Carolina, United States
McLeod Regional Medical Center
🇺🇸
Florence, South Carolina, United States
Geisinger Medical Center
🇺🇸
Danville, Pennsylvania, United States
Cancer Care Associates
🇺🇸
Oklahoma City, Oklahoma, United States
Saint Rita's Medical Center
🇺🇸
Lima, Ohio, United States
Cleveland Clinic Cancer Center Independence
🇺🇸
Independence, Ohio, United States
Medical X-Ray Center
🇺🇸
Sioux Falls, South Dakota, United States
The Methodist Hospital System
🇺🇸
Houston, Texas, United States
Kadlec Clinic Hematology and Oncology
🇺🇸
Kennewick, Washington, United States
Cottonwood Hospital Medical Center
🇺🇸
Murray, Utah, United States
Harrison HealthPartners Hematology and Oncology-Bremerton
🇺🇸
Bremerton, Washington, United States
LDS Hospital
🇺🇸
Salt Lake City, Utah, United States
Central Vermont Medical Center/National Life Cancer Treatment
🇺🇸
Berlin, Vermont, United States
Skagit Valley Hospital
🇺🇸
Mount Vernon, Washington, United States
McKay-Dee Hospital Center
🇺🇸
Ogden, Utah, United States
Huntsman Cancer Institute/University of Utah
🇺🇸
Salt Lake City, Utah, United States
University of Vermont College of Medicine
🇺🇸
Burlington, Vermont, United States
PeaceHealth Saint Joseph Medical Center
🇺🇸
Bellingham, Washington, United States
PeaceHealth United General Medical Center
🇺🇸
Sedro-Woolley, Washington, United States
West Virginia University Healthcare
🇺🇸
Morgantown, West Virginia, United States
University of Alabama at Birmingham Cancer Center
🇺🇸
Birmingham, Alabama, United States
Porter Adventist Hospital
🇺🇸
Denver, Colorado, United States
Colorado Cancer Research Program NCORP
🇺🇸
Denver, Colorado, United States
Rose Medical Center
🇺🇸
Denver, Colorado, United States
Mayo Clinic
🇺🇸
Rochester, Minnesota, United States
Washington University School of Medicine
🇺🇸
Saint Louis, Missouri, United States
Froedtert and the Medical College of Wisconsin
🇺🇸
Milwaukee, Wisconsin, United States
Presbyterian - Saint Lukes Medical Center - Health One
🇺🇸
Denver, Colorado, United States
SCL Health Saint Joseph Hospital
🇺🇸
Denver, Colorado, United States
McKee Medical Center
🇺🇸
Loveland, Colorado, United States
Penrose-Saint Francis Healthcare
🇺🇸
Colorado Springs, Colorado, United States
Saint Mary Corwin Medical Center
🇺🇸
Pueblo, Colorado, United States
SCL Health Lutheran Medical Center
🇺🇸
Wheat Ridge, Colorado, United States
North Memorial Medical Health Center
🇺🇸
Robbinsdale, Minnesota, United States
United Hospital
🇺🇸
Saint Paul, Minnesota, United States
Cotton O'Neil Cancer Center / Stormont Vail Health
🇺🇸
Topeka, Kansas, United States
Cancer Center of Kansas-Kingman
🇺🇸
Kingman, Kansas, United States
Cancer Center of Kansas - Parsons
🇺🇸
Parsons, Kansas, United States
Menorah Medical Center
🇺🇸
Overland Park, Kansas, United States
Cancer Center of Kansas - Wellington
🇺🇸
Wellington, Kansas, United States
Kinston Medical Specialists PA
🇺🇸
Kinston, North Carolina, United States
Wayne Memorial Hospital
🇺🇸
Goldsboro, North Carolina, United States
Siouxland Regional Cancer Center
🇺🇸
Sioux City, Iowa, United States
Lewistown Hospital
🇺🇸
Lewistown, Pennsylvania, United States
Community Cancer Center Foundation
🇺🇸
Normal, Illinois, United States
Cancer Center of Kansas - Chanute
🇺🇸
Chanute, Kansas, United States
Memorial University Medical Center
🇺🇸
Savannah, Georgia, United States
Edward H Kaplan MD and Associates
🇺🇸
Skokie, Illinois, United States
North Suburban Medical Center
🇺🇸
Thornton, Colorado, United States
Poudre Valley Hospital
🇺🇸
Fort Collins, Colorado, United States
Swedish Medical Center
🇺🇸
Englewood, Colorado, United States
Longmont United Hospital
🇺🇸
Longmont, Colorado, United States
Providence Alaska Medical Center
🇺🇸
Anchorage, Alaska, United States
Boulder Community Hospital
🇺🇸
Boulder, Colorado, United States
Mayo Clinic in Arizona
🇺🇸
Scottsdale, Arizona, United States
Sky Ridge Medical Center
🇺🇸
Lone Tree, Colorado, United States
MedStar Washington Hospital Center
🇺🇸
Washington, District of Columbia, United States
Saint Francis Hospital - Wilmington
🇺🇸
Wilmington, Delaware, United States
Christiana Care Health System-Christiana Hospital
🇺🇸
Newark, Delaware, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
🇺🇸
Hollywood, Florida, United States
Mount Sinai Medical Center
🇺🇸
Miami Beach, Florida, United States
Baptist MD Anderson Cancer Center
🇺🇸
Jacksonville, Florida, United States
Augusta University Medical Center
🇺🇸
Augusta, Georgia, United States
Hematology Oncology Associates of Eastern Idaho
🇺🇸
Idaho Falls, Idaho, United States
Heartland Cancer Research NCORP
🇺🇸
Decatur, Illinois, United States
Joliet Oncology-Hematology Associates Limited
🇺🇸
Joliet, Illinois, United States
Illinois CancerCare-Galesburg
🇺🇸
Galesburg, Illinois, United States
Saint Margaret's Hospital
🇺🇸
Spring Valley, Illinois, United States
Hinsdale Hematology Oncology Associates Incorporated
🇺🇸
Hinsdale, Illinois, United States
Kewanee Hospital
🇺🇸
Kewanee, Illinois, United States
Ottawa Regional Hospital and Healthcare Center
🇺🇸
Ottawa, Illinois, United States
Illinois CancerCare-Peoria
🇺🇸
Peoria, Illinois, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
🇺🇸
Pekin, Illinois, United States
Carle Cancer Center
🇺🇸
Urbana, Illinois, United States
IU Health La Porte Hospital
🇺🇸
La Porte, Indiana, United States
Franciscan Saint Anthony Health-Michigan City
🇺🇸
Michigan City, Indiana, United States
Northern Indiana Cancer Research Consortium
🇺🇸
South Bend, Indiana, United States
University of Iowa Healthcare Cancer Services Quad Cities
🇺🇸
Bettendorf, Iowa, United States
Lawrence Memorial Hospital
🇺🇸
Lawrence, Kansas, United States
Saint Luke's Regional Medical Center
🇺🇸
Sioux City, Iowa, United States
Cancer Center of Kansas - Fort Scott
🇺🇸
Fort Scott, Kansas, United States
Kansas City NCI Community Oncology Research Program
🇺🇸
Prairie Village, Kansas, United States
Shawnee Mission Medical Center-KCCC
🇺🇸
Shawnee Mission, Kansas, United States
Mary Bird Perkins Cancer Center/Terrebonne General Medical Center
🇺🇸
Houma, Louisiana, United States
Mary Bird Perkins Cancer Center
🇺🇸
Baton Rouge, Louisiana, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
🇺🇸
Wichita, Kansas, United States
Via Christi Regional Medical Center
🇺🇸
Wichita, Kansas, United States
Saint Francis Hospital and Medical Center - Topeka
🇺🇸
Topeka, Kansas, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
🇺🇸
Baltimore, Maryland, United States
Franklin Medical Center
🇺🇸
Greenfield, Massachusetts, United States
Bronson Methodist Hospital
🇺🇸
Kalamazoo, Michigan, United States
Lakeland Hospital
🇺🇸
Saint Joseph, Michigan, United States
Fairview Ridges Hospital
🇺🇸
Burnsville, Minnesota, United States
Providence Hospital-Southfield Cancer Center
🇺🇸
Southfield, Michigan, United States
Miller-Dwan Hospital
🇺🇸
Duluth, Minnesota, United States
Medini, Eitan MD (UIA Investigator)
🇺🇸
Alexandria, Minnesota, United States
Essentia Health Saint Mary's Medical Center
🇺🇸
Duluth, Minnesota, United States
Fairview-Southdale Hospital
🇺🇸
Edina, Minnesota, United States
Unity Hospital
🇺🇸
Fridley, Minnesota, United States
Swenson, Wade II, MD (UIA Investigator)
🇺🇸
Fergus Falls, Minnesota, United States
Minnesota Oncology Hematology PA-Maplewood
🇺🇸
Maplewood, Minnesota, United States
Etzell, Paul S MD (UIA Investigator)
🇺🇸
Fergus Falls, Minnesota, United States
Coborn Cancer Center at Saint Cloud Hospital
🇺🇸
Saint Cloud, Minnesota, United States
Saint Cloud Hospital
🇺🇸
Saint Cloud, Minnesota, United States
Hattiesburg Clinic - Hematology/Oncology Clinic
🇺🇸
Hattiesburg, Mississippi, United States
Liberty Radiation Oncology Center
🇺🇸
Liberty, Missouri, United States
Saint Luke's East - Lee's Summit
🇺🇸
Lee's Summit, Missouri, United States
Northern Rockies Radiation Oncology Center
🇺🇸
Billings, Montana, United States
Montana Cancer Consortium NCORP
🇺🇸
Billings, Montana, United States
Bozeman Deaconess Hospital
🇺🇸
Bozeman, Montana, United States
Internal Medicine of Bozeman
🇺🇸
Bozeman, Montana, United States
Guardian Oncology and Center for Wellness
🇺🇸
Missoula, Montana, United States
Community Medical Hospital
🇺🇸
Missoula, Montana, United States
Nevada Cancer Research Foundation CCOP
🇺🇸
Las Vegas, Nevada, United States
Cooper Hospital University Medical Center
🇺🇸
Camden, New Jersey, United States
Wilson Medical Center
🇺🇸
Wilson, North Carolina, United States
Rutgers Cancer Institute of New Jersey
🇺🇸
New Brunswick, New Jersey, United States
Southeastern Medical Oncology Center-Goldsboro
🇺🇸
Goldsboro, North Carolina, United States
Wayne Radiation Oncology
🇺🇸
Goldsboro, North Carolina, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
🇺🇸
New York, New York, United States
Roswell Park Cancer Institute
🇺🇸
Buffalo, New York, United States
Orange Regional Medical Center
🇺🇸
Middletown, New York, United States
Ohio State University Comprehensive Cancer Center
🇺🇸
Columbus, Ohio, United States
Cleveland Clinic Wooster Family Health and Surgery Center
🇺🇸
Wooster, Ohio, United States
Natalie Warren Bryant Cancer Center at Saint Francis
🇺🇸
Tulsa, Oklahoma, United States
Penn State Milton S Hershey Medical Center
🇺🇸
Hershey, Pennsylvania, United States
Scranton Hematology Oncology
🇺🇸
Scranton, Pennsylvania, United States
Geisinger Medical Group
🇺🇸
State College, Pennsylvania, United States
University of Tennessee - Knoxville
🇺🇸
Knoxville, Tennessee, United States
Sanford USD Medical Center - Sioux Falls
🇺🇸
Sioux Falls, South Dakota, United States
Avera McKennan Hospital and University Health Center
🇺🇸
Sioux Falls, South Dakota, United States
Sanford Cancer Center Oncology Clinic
🇺🇸
Sioux Falls, South Dakota, United States
Brooke Army Medical Center
🇺🇸
Fort Sam Houston, Texas, United States
Intermountain Medical Center
🇺🇸
Murray, Utah, United States
Logan Regional Hospital
🇺🇸
Logan, Utah, United States
Sandra L Maxwell Cancer Center
🇺🇸
Cedar City, Utah, United States
Utah Valley Regional Medical Center
🇺🇸
Provo, Utah, United States
Harborview Medical Center
🇺🇸
Seattle, Washington, United States
Minor and James Medical PLLC
🇺🇸
Seattle, Washington, United States
Wenatchee Valley Hospital and Clinics
🇺🇸
Wenatchee, Washington, United States
PeaceHealth Southwest Medical Center
🇺🇸
Vancouver, Washington, United States
Marshfield Clinic Cancer Center at Sacred Heart
🇺🇸
Eau Claire, Wisconsin, United States
Cancer Care Northwest - Spokane South
🇺🇸
Spokane, Washington, United States
Marshfield Clinic-Chippewa Center
🇺🇸
Chippewa Falls, Wisconsin, United States
Gundersen Lutheran Medical Center
🇺🇸
La Crosse, Wisconsin, United States
Sacred Heart Hospital
🇺🇸
Eau Claire, Wisconsin, United States
Marshfield Clinic
🇺🇸
Marshfield, Wisconsin, United States
Marshfield Medical Center
🇺🇸
Marshfield, Wisconsin, United States
Marshfield Clinic-Minocqua Center
🇺🇸
Minocqua, Wisconsin, United States
Marshfield Clinic-Rice Lake Center
🇺🇸
Rice Lake, Wisconsin, United States
ProHealth Oconomowoc Memorial Hospital
🇺🇸
Oconomowoc, Wisconsin, United States
Ascension Saint Mary's Hospital
🇺🇸
Rhinelander, Wisconsin, United States
ProHealth Waukesha Memorial Hospital
🇺🇸
Waukesha, Wisconsin, United States
Saint Michael's Hospital
🇺🇸
Stevens Point, Wisconsin, United States
Marshfield Clinic - Weston Center
🇺🇸
Weston, Wisconsin, United States
Marshfield Clinic - Wisconsin Rapids Center
🇺🇸
Wisconsin Rapids, Wisconsin, United States
Rambam Medical Center
🇮🇱
Haifa, Israel
The Medical Center of Aurora
🇺🇸
Aurora, Colorado, United States
Louisiana State University Health Science Center
🇺🇸
New Orleans, Louisiana, United States
University Medical Center New Orleans
🇺🇸
New Orleans, Louisiana, United States
Ochsner Medical Center Jefferson
🇺🇸
New Orleans, Louisiana, United States
Truman Medical Center
🇺🇸
Kansas City, Missouri, United States
Saint Luke's Hospital of Kansas City
🇺🇸
Kansas City, Missouri, United States
Saint Joseph Health Center
🇺🇸
Kansas City, Missouri, United States
North Kansas City Hospital
🇺🇸
Kansas City, Missouri, United States
Research Medical Center
🇺🇸
Kansas City, Missouri, United States
University of Florida Health Science Center - Gainesville
🇺🇸
Gainesville, Florida, United States
Montefiore Medical Center-Weiler Hospital
🇺🇸
Bronx, New York, United States
Montefiore Medical Center-Wakefield Campus
🇺🇸
Bronx, New York, United States
Montefiore Medical Center - Moses Campus
🇺🇸
Bronx, New York, United States
Mercy Capitol
🇺🇸
Des Moines, Iowa, United States
Iowa Methodist Medical Center
🇺🇸
Des Moines, Iowa, United States
Iowa-Wide Oncology Research Coalition NCORP
🇺🇸
Des Moines, Iowa, United States
Medical Oncology and Hematology Associates-Des Moines
🇺🇸
Des Moines, Iowa, United States
Medical Oncology and Hematology Associates-Laurel
🇺🇸
Des Moines, Iowa, United States
Mercy Medical Center - Des Moines
🇺🇸
Des Moines, Iowa, United States
Iowa Lutheran Hospital
🇺🇸
Des Moines, Iowa, United States
Cancer Center of Kansas - Newton
🇺🇸
Newton, Kansas, United States
Wilford Hall Medical Center
🇺🇸
Lackland Air Force Base, Texas, United States
Dixie Medical Center Regional Cancer Center
🇺🇸
Saint George, Utah, United States