Do the remaining insulin-producing cells in people with type 1 diabetes help to maintain good glucose control after exercise?
Not Applicable
Completed
- Conditions
- Type 1 diabetesNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN50072340
- Lead Sponsor
- ewcastle University
- Brief Summary
2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32747405/ results (added 05/10/2020) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35181926/ (added 14/06/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
1. Aged 18-65 years old
2. Clinically diagnosed Type 1 diabetes
3. Treated with exogenous insulin (pump or injection)
4. Free from diabetes complications
Exclusion Criteria
1. Type 1 diabetes participants duration of disease less than 1 year
2. HbA1c > 10% (86 mmol/mol)
3. Unable to complete maximal exercise test
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The amount of time interstitial glucose is spent in euglycaemia measured using blinded interstitial continuous glucose monitoring
- Secondary Outcome Measures
Name Time Method 1. Glycaemic variability (SD, CV%, MAGE, J-Index, CONGA, MAG, M-value)<br>2. Time spent: hypoglycaemic (<3.9mmol/L, <3.0mmol/L), hyperglycaemic (>10mmol/L, >13.9mmol/L, >16.7mmol/L)<br>3. Hypoglycaemia stage 1 (<3.9mmol/L for 15+ minutes) and stage 2 (<3.0mmol/L for 15+ minutes) and hyperglycaemia incidence level 1 (>10mmol for 15+ minutes) and level 2 (>13.9mmol for 15+ minutes)<br>4. Corrective bolus/carbohydrate intake