A non-randomization controlled trial for Jian-Pi Bu-Shen and Qu-Yu Tong-Luo method in the treatment of Diabetic nephropathy
- Conditions
- Diabetic kidney disease
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Aged 18-74 years old men and women;
2. Meet the diagnostic criteria of diabetic nephropathy or have a history of diabetes, urine protein negative, but glomerular filtration rate >=15ml/min*1.73m2 and <=59 ml/min*1.73m2.
1. Cannot provided Informed consent;
2. Pregnant or nursing women;
3. With heart failure in NYHA grade III or IV, a basic heart disease, physical activity significantly limited, less than the general physical activity or feel fatigue, palpitations, asthma or angina symptoms even at rest;
4. With cirrhosis;
5. With HIV infection or AIDS;
6. Patients who received chemotherapy or alkylating agent for malignant tumor in the past 2 years;
7. Patients who have previously been on dialysis for more than 1 month and / or organ or bone marrow transplantation;
8. Patients who received immunosuppressive therapy for primary kidney disease or systemic disease in the past 3 months;
9. With other primary and secondary renal diseases.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ACR;Renal function;TCM syndrome score;24-hour urine protein;
- Secondary Outcome Measures
Name Time Method Blood phosphorus;Blood calcium;Klotho;Blood fat;PTH;Depression self-rating scale;Blood sugar;Anxiety self-rating scale;Bone mineral density;Simple mental state scale;FGF2;echocardiographic;Kidney disease and quality of life questionnaire;FGF21;FGF23;Lateral abdominal plain film;