Clinical study to investigate the effects of anti-CD20 monoclonal antibody (Rituximab) in patients with refractory pulmonary arterial hypertension associated with connective tissue disease - Clinical study to investigate the effects of anti-CD20 monoclonal antibody (Rituximab) in patients with refractory pulmonary arterial hypertension associated with connective tissue disease

The University of Tokyo Hospital0 个研究点目标入组 6 人开始时间: 2015年1月24日最近更新: 2023年10月17日

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•1)Patients with pulmonary hypertension associated with left heart disease, chronic thromboembolic pulmonary hypertension, respiratory disease, and hypoxia 2)Patients with vasodilators (endothelin receptor antagonists, prostacyclin analogues and phosphodiesterase 5 inhibitors) started, or the dosage of the vasodilators changed within 4 weeks before the trial 3)Patients with malignancies or malignancy history within 5 years 4)Patients with sever liver diseases (AST(GOT) or ALT(GPT) over 100 U/L) 5)Patients with sever kidney diseases (serum creatinine over 3.0 mg/dL) 6)Patients with sever heart diseases 7)Patients with apparent active infectious diseases 8)Patients with hepatitis B virus carrier (patients with positive HBs antibody or HBc antibody should be monitored on their HBV-DNA monthly.(Exclude patients with history of HBV vaccination)) 9)Patients with history of serious infectious diseases

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