Chemoreflex Gain on Exercise
试验速览
- 阶段
- 1 期
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- chemoreflex gain on exercise
研究概览
简要总结
The purpose of this study is to assess chemoreflex gain on exercise.
详细描述
Normally breathing is controlled by a reflex that responds to the levels of carbon dioxide (CO2) in the blood. The change in breathing that results from a change in the blood's CO2 concentration is called the chemoreflex.
In heart failure, a condition where the heart muscle is damaged and can not pump as well, this reflex is exaggerated. The result of this can be breathing conditions characterised by patients hyperventilating at times and at other times taking very shallow breaths or even stopping altogether. In the past the only way of measuring this chemoreflex was to get patients to breathe into a large container and to rebreathe their exhaled air and allow the CO2 to rise over time, whilst keeping the oxygen constant. The proportion by which the ventilation increases with increasing carbon dioxide is the chemoreflex gain. Unfortunately, because this test takes a long time to conduct, requires specialist knowledge and equipment it has not been possible to measure this reflex on exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Volunteers: Males aged 18-80 years who are able to perform both running and cycling and can follow simple visual instructions.
- •Heart Failure Subjects: Males aged 18-80 with a clinical diagnosis of heart failure who are able to perform both running and cycling and can follow simple visual instructions.
排除标准
- •Chest pain of any cause within 4-6 days,
- •Pulmonary oedema,
- •Uncontrolled hypertension (systolic blood pressure > 220 mm Hg, diastolic >120 mm Hg),
- •Severe aortic stenosis,
- •Severe hypertrophic obstructive cardiomyopathy,
- •Untreated life threatening arrhythmia,
- •Dissecting aneurysm,
- •Recent surgery (within 4-6 weeks), COPD.
结局指标
主要结局
chemoreflex gain on exercise
时间窗: every minute
次要结局
- Reproducibility of chemoreflex gain on exercise(every minute)