Phase 1 Study of Protective Effect of Hyperbaric Oxygen Preconditioning on Brain and Myocardium Injury During CABG Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Injury
- Sponsor
- Xijing Hospital
- Enrollment
- 49
- Primary Endpoint
- Post operative cognitive dysfunction
- Status
- Completed
- Last Updated
- 16 years ago
Overview
Brief Summary
Animal studies have shown that preconditioning with hyperbaric oxygen can induce central nervous system and heart ischemic tolerance. This study was designed to determine the protective effect of hyperbaric oxygen preconditioning on brain and myocardium ischemia-reperfusion injury during coronary artery bypass graft surgery.
Detailed Description
60 patients scheduled to undergo coronary revascularization were recruited for this trial. Exclusion criteria included Emergency operation, age older than 80 years, learning difficulty, previous cerebrovascular disease, visual or hearing impairment, history of pneumothorax, Claustrophobia, middle ear disease, EF \< 35%. Patients were randomized either to the control group or hyperbaric oxygen group. The laboratory analysis of markers included S100B, NSE and troponin I. The assessment of cognitive dysfunction was performed 5 days before surgery and 7 days after surgery and haemodynamic measurements, length of stay in ICU, length of stay in hospital post-operation were recorded.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled to undergo coronary revascularization surgery.
Exclusion Criteria
- •Emergency operation
- •Age older than 80 years
- •Learning difficulty
- •Previous cerebrovascular disease
- •Visual or hearing impairment
- •History of pneumothorax, claustrophobia, middle ear disease, EF \< 35%
Outcomes
Primary Outcomes
Post operative cognitive dysfunction
Time Frame: 5 days before surgery and 7 days after surgery
Secondary Outcomes
- S100B protein,NSE and Troponin I(Within the first 3 days after surgery)