Corneal Endothelial Cell Injury Induced by Mitomycin-C

Not Applicable

Recruiting

• Conditions: Myopia
• Interventions: Procedure: Transepithelial PRK/MMC; Procedure: Alcohol-Assisted PRK/MMC

• Registration Number: NCT05548478
• Lead Sponsor: Al-Azhar University

Brief Summary

our study will investigate the effecacy of Mitomycin-C in TransEpi single step photorefractive keratectomy (PRK) and alcohol assisted PRK

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-09
• Study Start: 2022-09
• Study First Submitted: 2022-09-17
• Study First Submitted QC: 2022-09-17
• Last Update Submitted: 2022-09-17
• Study First Posted: 2022-09-21
• Last Update Posted: 2022-09-21
• Primary Completion: 2023-02
• Study Completion: 2023-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age over 18 years.
• Primary myopia or compound myopic astigmatism.
• Preoperative manifest refraction spherical equivalent (MRSE) within the range of -1.0 to 8 D
• Stable refractive error for at least 12 months before the surgery.
• Contact lens discontinuation for at least 3 weeks.
• Estimated corneal stromal bed thickness of more than 300mm at the thinnest point

Exclusion Criteria

• Unwilling to participate in the study.
• Previous ocular surgery
• Any diagnosed ocular disease
• History of ocular trauma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TransEpi single step PRK	Transepithelial PRK/MMC	-
alcohol assisted PRK	Alcohol-Assisted PRK/MMC	-

Primary Outcome Measures

Name	Time	Method
Endothelial cell Density	at 3rd month	will be measured by Specular microscopy

Trial Locations

Locations (1)

Ehab tharwat; 🇪🇬 Damieta, New Damietta, Egypt