The effect of concentrated growth factor (SGF) and Platelet Rich Fibrin (PRF) on post endodontic surgery healing : A randomized clinical trial
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Surface area reduction
研究概览
简要总结
The present studywill be conducted in the Department of Conservative Dentistry andEndodontics, Faculty of Dental Sciences, King G eorge’s Medical University(KGMU), Lucknow.
Background
The overall success of a periapical surgery is assessed in terms ofregeneration of functional periradicular tissues. The regenerative potential ofplatelets has been well documented. The use of concentrated growth factors (CGF),a new family of autologous platelet concentrates, has been under study as a solematerial for bone regeneration after periapical surgery.
Purpose
To study theefficacy of CGF and PRF in neo angiogenesis and bone healing using colordoppler and CBCT
•Study design :
This is a randomized clinical trial.
•Investigating procedures :
•The following investigations will bedone at baseline and follow up appointments
1.CBCT
2.Color doppler
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients within 18–40 years of age.
- •Single rooted, anterior teeth.
- •Teeth with peri apical radiolucency indicated for surgery.
- •Patients who are not on any medication affecting periapical healing.
- •(corticosteroids, chemotherapeutic agents, nonâ€steroidal anti†inflammatory drugs (NSAIDs), antibiotics, anticoagulants and drugs which reduce osteoclastic activity).
排除标准
- •Patients who did not give their consent for participating in the study.
- •Patients having insufficient motivation to report back for follow up visits.
- •Patients with any systemic diseases like diabetes mellitus, hypertension, hepatitis, Human immunodeficiency virus, bone disorders, autoâ€immune disorders.
- •Surgical retreatment cases.
- •Pregnant females.
- •Patients with periodontally compromised teeth.
结局指标
主要结局
Surface area reduction
时间窗: 0,1,3,6 months
次要结局
- Peak systolic velocity(0,1,3,6 months)