The effect of blood-derived products on bone healing after surgery : A randomized clinical trial

Phase 3

Not yet recruiting

• Conditions: Other dentofacial anomalies, (2) ICD-10 Condition: K046||Periapical abscess with sinus,

• Registration Number: CTRI/2023/10/058270
• Lead Sponsor: Supriya Choudhary

Brief Summary

The present studywill be conducted in the Department of Conservative Dentistry andEndodontics, Faculty of Dental Sciences, King G eorge’s Medical University(KGMU), Lucknow.

Background

The overall success of a periapical surgery is assessed in terms ofregeneration of functional periradicular tissues. The regenerative potential ofplatelets has been well documented. The use of concentrated growth factors (CGF),a new family of autologous platelet concentrates, has been under study as a solematerial for bone regeneration after periapical surgery.

Purpose

To study theefficacy of CGF and PRF in neo angiogenesis and bone healing using colordoppler and CBCT

•Study design :

This is a randomized clinical trial.

•Investigating procedures :

•The following investigations will bedone at baseline and follow up appointments

1.CBCT

2.Color doppler

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-10
• Last Update Posted: 2023-09-27

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• All patients within 18–40 years of age.
• Single rooted, anterior teeth.
• Teeth with peri apical radiolucency indicated for surgery.
• Patients who are not on any medication affecting periapical healing.
• (corticosteroids, chemotherapeutic agents, nonâ€steroidal anti†inflammatory drugs (NSAIDs), antibiotics, anticoagulants and drugs which reduce osteoclastic activity).

Exclusion Criteria

• Patients who did not give their consent for participating in the study.
• Patients having insufficient motivation to report back for follow up visits.
• Patients with any systemic diseases like diabetes mellitus, hypertension, hepatitis, Human immunodeficiency virus, bone disorders, autoâ€immune disorders.
• Surgical retreatment cases.
• Pregnant females.
• Patients with periodontally compromised teeth.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Surface area reduction	0,1,3,6 months

Secondary Outcome Measures

Name	Time	Method
Peak systolic velocity	0,1,3,6 months

Trial Locations

Locations (1)

King Georges Medical University; 🇮🇳 Lucknow, UTTAR PRADESH, India

King Georges Medical University

🇮🇳Lucknow, UTTAR PRADESH, India

Dr Supriya Choudhary

Principal investigator

9731565808

supriyachoudhary2596@gmail.com