Comparing examination of the effect of transcranial direct current stimulation (tDCS) of genetically defined ataxias and in a mouse model.

Phase 2

• Conditions: SCA6; G11.2; Late-onset cerebellar ataxia

• Registration Number: DRKS00017021
• Lead Sponsor: Klinik für Neurologie, Universitätsklinikum Essen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Written informed consent of the patient/paticipant
2. Minimum age: 18 years
3. Patients: Existence of a genetically secured SCA6
4. Sufficient knowledge of the German language to understand the written consent and the experimental instructions

Exclusion Criteria

1. Healthy controls: Existence of a neurological (incl. epileptic seizures), psychiatric or severe orthopaedic disorders
2. SCA6 patients: Existence of neurological disorders other than SCA6 (incl. epileptic seizures), psychiatric or severe orthopaedic disorders
3. Drug oder alcohol abuse
4. Intake of centrally-acting drugs
5. Persons with consuming diseases or in bad general health condition
6. (Adult) persons that are not contractually capable and persons in regulatory or judical custody

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change of Cerebellar Brain Inhibition by application of cerebellar transcranial Direct Current Stimulation

Secondary Outcome Measures

Name	Time	Method
1. Change of eyeblink conditioning by application of cerebellar tDCS <br>2. Correlation between disease duration and change of CBI<br>3. Correlation between ataxia severity (using ataxia-scores; SARA, ICARS, SCAFI) and change in CBI<br>4. Comparison with the mouse model of SCA6