Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Changes in gait efficiency during steady state walking
研究概览
简要总结
The purpose of this study is to investigate if a beetroot juice supplement can improve oxygen capacity during walking tasks at a submaximal and maximal effort in people greater than 6 months following stroke.
详细描述
During this study, participants will perform baseline measurements such as walking and balance tests. During baseline testing, participants will be asked to perform a maximal exertion test while walking on a treadmill to determine the speed for a submaximal walking test. One week after baseline testing, the participant will have an intervention session where they drink either a beetroot juice supplement or a placebo. The placebo will taste similar to the beetroot juice and participants may not be able to tell the difference between the two different supplements. After a week, the participant will return to the lab and drink the other supplement. For example, if the participant drank the beetroot juice in the first session, then they will drink the placebo in the second session. During each intervention session, the participant will be asked to perform two treadmill tests, one with submaximal effort and one with maximal effort. After the walking tests, they will drink either the beetroot juice or placebo and have their blood drawn. They will wait at the hospital for 2-3 hours and have their blood drawn again. The participants will then complete the two treadmill tests again. The two intervention sessions will last about 4-6 hours for each session. Participation in the study will last 4-6 weeks including screening and baseline testing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adults aged 18-89 years
- •diagnosis of chronic hemiparesis following unilateral stroke (greater than six months)
- •ability to ambulate at least 0.3 m/s, with or without using an assistive device or bracing below the knee
- •ability to read and understand English
- •follow three-step commands
排除标准
- •presence of cerebellar deficits
- •any other neurological or orthopedic deficits that would limit walking ability
- •cannot receive physical therapy for gait-related impairments
- •uncontrolled metabolic, respiratory, and cardiovascular disease
结局指标
主要结局
Changes in gait efficiency during steady state walking
时间窗: Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion
Oxygen Consumption during steady state walking prior to and following placebo or beetroot juice ingestion
Changes in plasma levels of Nitrate and Nitrite
时间窗: Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion
Blood samples taken prior and following ingestion of either the beetroot juice or placebo supplements.
次要结局
- Changes in peak Treadmill Speed(Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion)
- Changes in peak oxygen consumption during maximum gait speed(Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion.)
- Changes in peak heart rate during the graded treadmill test(Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion.)
研究者
George Hornby
Professor
Indiana University