Bedside Ultrasound of Inferior Vena Cava Collapsibility in Emergency Department Patients Presenting With Severe Sepsis and Septic Shock
试验速览
- 阶段
- 不适用
- 入组人数
- 112
- 试验地点
- 2
- 主要终点
- Mean baseline inferior vena cava collapsibility index
研究概览
简要总结
There is debate regarding the use of non invasive (ultrasound assessed) parameters of fluid volume status in patients with sepsis.
To establish the role of inferior vena cava ultrasound in guiding fluid resuscitation we first need to define the inferior vena cava collapsibility index in this population of patients.
The research question is: In adult patients with sepsis, severe sepsis and septic shock what is the mean baseline inferior vena cava collapsibility index (IVCCI) prior to fluid resuscitation.
详细描述
The study is an interventional cohort study using a convenience sample of adult patients in a university teaching hospital Emergency Department.
Eligible participants who consent to partake in the trial will have an ultrasound assessment of their inferior vena cava performed and the IVCCI will be calculated at enrolment.
Care will be provided in line with the published guidelines on sepsis management from the Surviving Sepsis Campaign and the College of Emergency Medicine.
A sample size calculation has been performed which indicates that 112 patient with severe sepsis or septic shock will need to be enrolled.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients
- •signs and symptoms of infection with 2 or more SIRS criteria (pulse rate >90/min, Temp > 38 Celsius < 36 Celsius, Respiratory rate > 20 breaths per minute, or white cell count >12 or <4 x 10^9/L)
排除标准
- •in relation to this episode of care: Prior cardio pulmonary resuscitation, acute myocardial infarction, trauma, pregnancy or patient requiring immediate surgery.
- •Patients who have received more than 20ml/Kg of IV fluid in the pre hospital environment
- •Patients with known tricuspid regurgitation, congestive heart failure or pulmonary hypertension
- •Patients receiving palliative terminal supportive care
结局指标
主要结局
Mean baseline inferior vena cava collapsibility index
时间窗: At enrollment
次要结局
未报告次要终点
研究者
Simon Richards
Programme Leader Medical Ultrasound
Teesside University