The in-vivo extraction of nicotine and flavor compounds from a single dose of a non-tobacco-based nicotine pouch (ZYN®) compared with conventional, tobacco-based Swedish snus among current, daily snus users

Swedish Match North Europe0 个研究点目标入组 20 人开始时间: 2017年11月21日最近更新: 2024年2月27日

试验速览

2022 Results article in https://doi.org/10.3390/separations9020052 (added 15/02/2022)

•1. Snus user, with a minimum weekly consumption of three or more snus cans (brands with nicotine content <1%) or two or more cans (brands with nicotine content >1%) since =1 year
•2. Consent to participate voluntarily and sign Informed Consent Form prior to any study procedure
•3. Healthy male/female, age =19. Female subjects should have a negative pregnancy test.
•4. Willing and able to comply with study procedures
•5. A heart rate increase = 10 beats/min with first use of snus in the morning after overnight abstinence from any nicotine exposure

•1. A history or presence of diagnosed hypertension or any cardiovascular disease
•2. Surgery within 6 months of the screening visit that, in the opinion of the investigator, could negatively impact on the subject’s participation in the clinical study
•3. Any surgical or medical condition, which, in the judgment of the clinical investigator, might interfere with the absorption, distribution, metabolism or excretion of the drug
•4. Subjects who are pregnant

发起方

Swedish Match North Europe