Frailty in Hip Fracture Patients Treated With Surgery; the Role of Simple Inflammatory Biomarkers. An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 4
- 主要终点
- Frailty status
研究概览
简要总结
We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.
详细描述
Frailty (F) is a prevalent syndrome among elderly patient with hip fractures (HF) and has been linked to poor prognosis. Inflammatory biomarkers have been used as prognostic indexes in patients with HF. We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age >65 years, ASA PS I-III, non- institutionalized, able to communicate patients
排除标准
- •Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate
结局指标
主要结局
Frailty status
时间窗: preoperatively
Frailty will be categorized based on the validated Groningen Frailty Indicator (GFI) as non-frail (NF, score 0,1), pre-frail (PF, score 2, 3) and severe frail (SF, score \>4).
Inflammatory biomarkers
时间窗: preoperatively
Upon admission and immediate before surgery upper limits of white blood cells (WBC) within normal range (WBC \>8 10\^3/μL), NLR (neutrophils/lymphocytes), PLR (platelets/lymphocytes), CRP (C-reactive protein) and CLR (CRP/lymphocytes), will be recorded.
次要结局
未报告次要终点
研究者
Elena Arnaoutoglou
Chair, Professor of Anaesthesiology
University of Thessaly